Klotho serum levels are not reduced in type 2 diabetes and MVD. (A) No differences in serum sKlotho levels are present between healthy control subjects and type 2 diabetes patients with and without MVD. (B) Within type 2 diabetes patients, no difference in sKlotho levels between patients with or without MVD is present. (C) Similarly, when comparing non-diabetic patients with MVD with healthy control subjects no difference in sKlotho concentration was detected. Data are expressed as Tukey’s box-and-whisker plots.