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Figure 6 | Cardiovascular Diabetology

Figure 6

From: Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation

Figure 6

Additional synchrotron radiation angiograms of the coronary vasculature in two diabetic rats showing segmental constrictions. Baseline lactate infusion (A &B), ACh infusion (C &D; 3.0 μg/kg/min), following administration of L-NAME (10 mg/kg iv. bolus) and meclofenamate ( combined, E &F; 2 mg/kg iv. bolus) and subsequent combined + fasudil treatment (G &H; 10 mg/kg iv). A &B, Baseline response to vehicle infusion. C &D, Both diabetics maintained larger vessel ID than baseline (black asterisks). E &F, Diabetic focal and segmental vasoconstrictions (white arrows). G &H, Restoration of medium and small arteries to baseline ID, dilation (black asterisks) and recruitment of newly visualised small arteries and arterioles relative to baseline (arrowheads). ‘w’ is a 50 μm tungsten wire for vessel ID determination.

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