Myocardial ROCK1 and ROCK2 immunohistochemistry in control and diabetic rats. ROCK1 expression (C) in control (A) and diabetic (B) rats (40× objective). ROCK2 expression (F) in control (D) and diabetic (E) rats (20× objective). ROCK1 expression was not significantly different between control and diabetic groups, although there was a trend towards increased ROCK1 expression in diabetic rodents. ROCK2 expression was borderline significantly increased (P < 0.053) in diabetic compared to control animals. Control, n = 6 and diabetic, n = 7. Values expressed as mean ± SEM.