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Table 2 Clinical and laboratory data for 124 patients with type 2 diabetes divided into quartiles of serum osteoprotegerin levels (< 5.6; 5.6-8.4; 8.5-52.7; and 52.8-9027 pg/ml)

From: Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes

 

1st quartile

2nd quartile

3rd quartile

4th quartile

P value

Subjects (male/female)

31(25/6)

31(20/11)

31(23/8)

31(20/11)

 

Age (years)

61.0±1.2

66.3±1.4*

65.9±1.5

69.6±1.4**

0.001

Height (cm)

165.3±1.4

158.3±1.4**

164.6±1.1##

158.8±1.5**,$

0.001

Weight (kg)

68.6±2.4

59.6±1.7*

66.7±2.5

60.0±1.7*

0.003

BMI

24.9±0.7

23.7±0.5

24.5±0.7

23.6±0.5

0.366

Duration of diabetes mellitus (years)

12.0±1.4

16.9±1.6

14.7±1.4

15.2±1.4

0.142

Systolic blood pressure (mmHg)

127.0±2.6

133.6±2.5

136.1±4.6

140.7±2.6*

0.029

Diastolic blood pressure (mmHg)

74.7±1.5

75.0±1.6

74.9±1.7

75.7±1.7

0.975

FMD (%)

4.0±0.5

4.4±0.4

4.2±0.4

3.0±0.7

0.178

Mean IMT (mm)

0.95±0.05

1.07±0.06

1.13±0.07

1.04±0.09

0.337

HbA1c (NGSP) (%)

8.0±0.4

7.6±0.2

7.9±0.2

7.4±0.2

0.371

Total cholesterol (mg/dl)

192.1±7.7

191.6±4.6

188.1±6.4

192.4±4.7

0.953

Triglyceride (mg/dl)

136.6±12.9

129.7±12.6

120.5±9.0

137.1±10.8

0.709

HDL-Cholesterol (mg/dl)

47.8±2.3

51.4±2.7

55.2±2.3

51.7±2.3

0.210

LDL-Cholesterol (mg/dl)

111.7±7.4

113.8±4.3

109.0±5.2

113.0±5.2

0.937

Creatinine (mg/dl)

0.78±0.03

0.79±0.03

0.81±0.04

0.83±0.05

0.721

eGFR (ml/min/1.73m2)

79.5±3.7

70.0±3.0

74.4±4.1

69.2±3.4

0.159

Albuminuria (mg/g creatinine)

75.4±27.9

146.8±37.6

173.7±43.6

117.4±53.6

0.357

Adiponectin (μg/ml)

5.8±0.7

8.5±1.1

9.0±1.6

12.2±1.0**

0.002

Osteocalcin (ng/ml)

1.6±0.2

1.7±0.4

1.4±0.2

1.9±0.3

0.596

25-hydroxyvitamin D3 (nmol/l)

93.1±7.7

103.4±7.3

93.9±10.1

61.9±5.6*,##,$

0.002

FGF23 (pg/ml)

32.7±2.8

31.3±3.1

39.0±4.5

34.8±2.2

0.370

Ca (mg/dl)

9.3±0.05

9.4±0.06

9.4±0.07

9.3±0.07

0.499

iP (mg/dl)

3.6±0.09

3.6±0.09

3.6±0.08

3.5±0.08

0.937

  1. Values are shown as mean±SE and were analyzed by ANOVA. eGFR: estimated glomerular filtration rate. * P< 0.05 vs. 1st quartile. ** P < 0.01 vs. 1st quartile. # P < 0.05 vs. 2nd quartile. ## P < 0.01 vs. 2nd quartile. $ P < 0.05 vs. 3rd quartile. $$ P<0.01 vs. 3rd quartile.