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Figure 8 | Cardiovascular Diabetology

Figure 8

From: Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart

Figure 8

Effects of diabetes and 4 weeks of exercise on the interaction of mSin3A/HDAC1/2 with OGT and O-GlcNAc in type 2 diabetic db/db and non-diabetic C57BL/6J hearts. (A) Immunoblot and (B-F) blot quantification showing the O-GlcNAc modification and the association of the mSin3A/REST/HDAC1/2 complex with OGT in C57BL/6J (C57) and db/db (db) mice who were treadmill exercise trained (Ex) or sedentary (Sed) for 4 weeks. N = 6 per group. * Significant effect of genotype within exercise group, P < 0.05. # Significant effect of exercise within a genotype group, P < 0.05. ‡ Significant main effect of exercise, P < 0.05.

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Cardiovascular Diabetology

ISSN: 1475-2840