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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart

Figure 4

Effects of 1 and 4 weeks of treadmill exercise on total protein O-GlcNAcylation in type 2 diabetic db/db and non-diabetic C57BL/6J hearts. (A) Western blot and (B-E) quantification of total protein O-GlcNAcylation in ventricular tissue from C57 mice that were treadmill exercised (Ex) or sedentary (Sed) for 1 or 4 weeks. (F) Western blot and (G-J) quantification of protein O-GlcNAcylation levels in ventricular tissue from Ex or Sed (db) mice. O-GlcNAc levels are normalized to the loading control calsequestrin (Csq). N=6 per group. * Significant effect of time within an exercise group, P<0.05. # Significant effect of exercise within a time point, P<0.05. ‡ Significant interaction of exercise group x time, P<0.05.

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Cardiovascular Diabetology

ISSN: 1475-2840