Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus

Table 2 Correlation coefficients between L_RHI and markers of diabetic control and various nonglycemic metabolic variables

	HbA1c	Average^a	SD^a	MAGE^a	MPPGE^a	Time at			LDL-C	HDL-C	TG	SBP	DBP
	HbA1c	Average^a	SD^a	MAGE^a	MPPGE^a	<70^a(n=12)	≥140^a	≥200^a	LDL-C	HDL-C	TG	SBP	DBP
Average^a (n=57)	0.14
SD^a (n=57)	−0.16	0.36**
MAGE^a (n=57)	−0.06	0.30*	0.79**
MMPGE^a (n=57)	0.01	0.37**	0.64**	0.58**
Time at <70^a with hypoglycemia (n=12)	0.29	−0.69**	−0.38	−0.70*	−0.19
Time at ≥140^a (n=57)	0.12	0.84**	0.27*	0.18	0.32*	−0.68^*
Time at ≥200^a (n=57)	0.14	0.95**	0.43**	0.37**	0.39*	−0.70*	0.76**
LDL-C (n=57)	0.26	−0.01	−0.23	−0.13	0.04	0.65*	−0.10	−0.04
HDL-C (n=57)	−0.17	0.01	0.31*	0.04	0.19	0.03	0.17	0.05	0.06
TG (n=57)	0.27*	0.05	−0.21	−0.03	0.06	−0.33	0.04	0.01	0.16	−0.28*
SBP (n=57)	−0.07	−0.25	−0.09	0.01	−0.03	−0.07	−0.19	−0.22	−0.07	−0.18	0.05
DBP (n=57)	0.20	−0.20	−0.27*	−0.12	−0.10	−0.07	−0.16	−0.22	0.09	−0.26*	0.17	0.65**
L_RHI (n=57)	0.12	−0.24	−0.50**	−0.57**	−0.41**	−0.59*	−0.20	−0.29*	0.17	−0.14	0.01	0.11	0.09

^a Measured by the continuous glucose monitoring system.
Data are results of Pearson correlation analysis for normally distributed variables and Spearman rank correlation for variables with skewed distribution. *P<0.05, **P<0.01.
Abbreviations: HbA1c hemoglobin A1c; SD standard deviation; MAGE, mean amplitude of glycemic excursions; MPPGE mean postprandial glucose excursions; LDL-C low-density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; TG triglyceride; SBP systolic blood pressure; DBP diastolic blood pressure; L_RHI the natural logarithmic scaled reactive hyperemia index.

ISSN: 1475-2840