Skip to main content

Table 2 Parameters of glucose variability in patients taking vildagliptin (100 mg daily) or sitagliptin (50 mg daily)

From: Comparison of vildagliptin twice daily vs. sitagliptin once daily using continuous glucose monitoring (CGM): Crossover pilot study (J-VICTORIA study)

  Vildagliptin Sitagliptin P-value
24-h mean glucose level (mg/dL) 142.1 ± 14.0 153.2 ± 29.7 0.012*
0:00 to 08:00 (night) mean glucose level (mg/dL) 117.4 ± 22.1 130.9 ± 26.3 0.042*
08:00 to 24:00 (day) mean glucose level (mg/dL) 154.1 ± 25.6 164.4 ± 35.3 0.043*
SD over 24 h (mg/dL) 35.5 ± 12.6 37.0 ± 13.9 0.542
Preprandial glucose level (mg/dL) 110.5 ± 33.5 129.4 ± 45.1 0.040*
Preprandial glucose level (mg/dL) 128.1 ± 16.2 133.5 ± 26.8 0.282
lunch 109.1 ± 22.2 120.9 ± 44.8 0.165
Highest postprandial glucose level within 3 hours after each meal (mg/dL) 112.4 ± 21.1 116.6 ± 24.7 0.221
Highest postprandial glucose level within 3 hours after each meal (mg/dL) 211.0 ± 40.0 228.0 ± 58.4 0.117
lunch 188.6 ±37.7 203.1 ± 50.3 0.172
supper 206.1 ± 40.2 223.2 ± 43.5 0.015*
Time from start of meal to the highest postprandial glucose level (minutes)    
breakfast 76.0 ± 18.0 86.0 ± 28.4 0.204
lunch 93.3 ± 30.2 99.0 ± 35.6 0.579
supper 81.8 ± 24.6 93.0 ± 26.4 0.223
Differences between preprandial and highest postprandial glucose level for each meal (mg/dL)    
breakfast 83.0 ± 37.1 94.5 ± 46.3 0.185
lunch 79.5 ± 31.8 82.3 ± 33.9 0.774
supper 93.7 ± 35.7 106.6 ± 43.2 0.065
AUC (180 mg/dL) for glycemic variability within 3 h of each meal (mg·min/dL)    
breakfast 484.3 ± 541.1 897.9 ± 1097 0.025*
lunch 306.0 ± 554.8 630.5 ± 1017.2 0.152
supper 523.5 ± 618.3 703.4 ± 676.4 0.106
AOC (<70 mg·/dL) for glycemic variability in 24 h
(mg·min/dL)
   
  95.6 ± 243.0 16.2 ± 61.2 0.183
  1. Data are mean ± standard deviation. Paired-sample t-test. * p < 0.05.
  2. AUC = area under the curve; AOC = area over the curve.