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Figure 4 | Cardiovascular Diabetology

Figure 4

From: The effects of low-dose Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function

Figure 4

Effects of CML and CEL on the MAPK and AKT signaling pathways in EPCs. (A) After incubation of EPCs with different concentrations of CML or CEL for 24 hours, aliquots of cell lysate were subjected to western blot analysis. (B) The quantities of phosphorylated and total kinases were estimated using Quantity One software. CML and CEL inhibited phosphorylation of MAPKs, including ERK1/2, JNK1, and p38 MAPK, in a dose-dependent manner, but did not inhibit AKT. Similar results were obtained in three separate experiments. Data were expressed as mean ± SD. *p<0.05 vs. control, #p<0.01 vs. control

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Cardiovascular Diabetology

ISSN: 1475-2840