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Figure 3 | Cardiovascular Diabetology

Figure 3

From: The effects of low-dose Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function

Figure 3

Regulation of RAGE expressions in EPCs incubated with different concentrations of CML/CEL for different times. (A) In the concentration-dependent experiment, EPCs were incubated with 250, 500, or 1000 μg/L of CML, CEL, or control for 72 hours. In the time-dependent experiment, EPCs were incubated with 500 μg/L of CML or CEL for 0, 24, 48, or 72 hours. Aliquots of cell lysate were then subjected to western blot analysis. (B) Bar graph. No CML or CEL-induced difference in RAGE expression was observed in EPCs. Results were expressed as mean ± SD of three independent experiments.

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Cardiovascular Diabetology

ISSN: 1475-2840