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Table 3 Numbers and infarct size

From: Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury

 

Condition

Wild type

Ob/ob

DKO

  

Sham

IR

Sham

IR

Sham

IR

N experiments (survivors)

Untreated

9 (9)

12 (10)

7 (7)

11 (6)

7 (7)

9 (7)

 

Diet

  

9 (7)

11 (7)

9 (7)

9 (8)

 

ACE-I

6 (6)

8 (6)

10 (8)

10 (8)

8 (8)

10 (8)

Area at risk (% of heart)

Untreated

0 ± 0

14.7 ± 7.5

0 ± 0

14.0 ± 6.7

0 ± 0

18.2 ± 7.2

 

Diet

  

0 ± 0

17.8 ± 3.4

0 ± 0

16.4 ± 8.6

 

ACE-I

0 ± 0

17.0 ± 7.1

0 ± 0

17.1 ± 3.4

0 ± 0

15.3 ± 5.6

Infarct size (% of area at risk)

Untreated

0 ± 0

49.3 ± 6.8b

0 ± 0

72.4 ± 7.2ab

0 ± 0

67.2 ± 6.1ab

 

Diet

  

0 ± 0

68.4 ± 9.8ab

0 ± 0

70 ± 11.9ab

 

ACE-I

0 ± 0

55.1 ± 5.7b

0 ± 0

69 ± 8.1ab

0 ± 0

68.8 ± 9.9ab

  1. ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); a” p < 0.05 versus WT same treatment, same condition (sham or IR); “b” p < 0.05 versus sham, same genotype, same treatment.