Condition | Wild type | Ob/ob | DKO | ||||
---|---|---|---|---|---|---|---|
Sham | IR | Sham | IR | Sham | IR | ||
Heart rate (bpm) | Untreated | 575 ± 40 | 560±62 | 526 ± 44a | 540±41 | 523 ± 29a | 513±38 |
Diet | 504 ± 30a | 500 ± 31 | 503 ± 34a | 516±51 | |||
ACE-I | 548 ± 33 | 524 ± 36 | 505 ± 29 | 492±33 | 499 ± 51 | 509±68 | |
Stroke volume (μl) | Untreated | 16.2 ± 5.3 | 6.8±3.2c | 14.8 ± 3.1 | 12.0±4.3a | 10.1 ± 5.1a | 9.6±4.1 |
Diet | 13.6 ± 6.0 | 14.2±7.0a | 11.8 ± 5.1 | 12.7±6.1a | |||
ACE-I | 16.5 ± 4.9 | 8.1 ± 1.6c | 14.0 ± 3.2 | 12.6±4.2a | 15.1 ± 6.1 | 12.4±3.0a | |
Stroke work (mmHg*μl) | Untreated | 1256 ± 328 | 263±167c | 835 ± 189a | 509±181ac | 606 ± 269a | 409±199 |
Diet | 804 ± 546 | 667±336a | 627 ± 272a | 676±332a | |||
ACE-I | 877 ± 399 | 369 ± 158c | 788 ± 251 | 581±230 | 780 ± 408 | 563±170 | |
P sys (mmHg) | Untreated | 80.5 ± 18.2 | 55.1±10.6c | 68.7 ± 7.5 | 62.5±2.7 | 69.5 ± 11.1 | 62.7±10.6 |
Diet | 68.4 ± 10.8 | 60.4±5.9 | 67.1 ± 12.6 | 65.0±5.5a | |||
ACE-I | 62.9 ± 11.9 | 61.9 ± 19.9 | 67.9 ± 6.9 | 59.2±7.5c | 61.4 ± 6.2 | 56.1±8.1d | |
P ed (mmHg) | Untreated | 3.0 ± 0.7 | 2.9±1.2 | 3.6 ± 0.7 | 6.6±3.3ac | 4.8 ± 2.3a | 6.6±2.4a |
Diet | 3.0 ± 1.1 | 4.3±1.2a | 3.8 ± 1.3 | 4.3±1.5ab | |||
ACE-I | 3.6 ± 2.0 | 2.9 ± 2.3 | 4.5 ± 0.9d | 5.0±1.5 | 3.7 ± 0.9 | 3.4±1.5b | |
PRSW (mmHg) | Untreated | 88.8 ± 5.5 | 61.5 ± 11.6c | 64 ± 2.6a | 48.5 ± 3.3ac | 57.1 ± 4.6ae | 46.2 ± 8.8ac |
Diet | 65.4 ± 1.9a | 51 ± 1.9ac | 58 ± 2.8ae | 49.7 ± 3ac | |||
ACE-I | 87.4 ± 4.4 | 60.2 ± 6.4c | 71.8 ± 3.2abd | 52.1 ± 3.4ac | 66.3 ± 5abde | 51.2 ± 3.4ac | |
E es (mmHg/μl) | Untreated | 8.3 ± 2.5 | 6.4±1.5 | 5.1 ± 0.4a | 4.7±1.5 | 6.5 ± 2.4 | 4.5±0.8a |
Diet | 6.6 ± 2.1 | 4.5±1.1ac | 5.1 ± 1.2a | 5.3±1.2 | |||
ACE-I | 6.0 ± 1.0 | 6.8 ± 2.0 | 5.5 ± 1.7 | 4.6±1.7 | 5.6 ± 1.3 | 4.4±1.3a | |
Tau (ms) | Untreated | 6.3 ± 1.2 | 7.6±2.2 | 6.2 ± 0.5 | 6.4±1.0 | 6.9 ± 0.9 | 7.2±0.7 |
Diet | 6.9 ± 0.5b | 7.7±0.8bc | 6.8 ± 0.6 | 7.3±1.2 | |||
ACE-I | 6.6 ± 1.5 | 7.4 ± 1.5 | 8.0 ± 1.1bd | 8.8±1.5b | 7.4 ± 0.8 | 7.1±1.1e | |
EDPVR (mmHg/μl) | Untreated | 0.2 ± 0.2 | 0.4±0.2 | 0.4 ± 0.3 | 0.5±0.3 | 0.6 ± 0.4a | 0.3±0.1 |
Diet | 0.2 ± 0.2 | 0.2±0.1 | 0.2 ± 0.2 | 0.2±0.1ab | |||
ACE-I | 0.2 ± 0.1 | 0.4 ± 0.3 | 0.4 ± 0.1 | 0.3±0.1 | 0.3 ± 0.1be | 0.3±0.1d | |
E a (mmHg/μl) | Untreated | 4.8 ± 1.5 | 8.1 ± 2.4c | 4.0 ± 0.9 | 5.0±2.0a | 6.8 ± 3.5 | 5.6±1.8a |
Diet | 4.9 ± 1.8 | 4.8±2.7a | 5.2 ± 2.2 | 5.4±2.1a | |||
ACE-I | 3.3 ± 0.6b | 6.9 ± 1.3c | 4.6 ± 1.5 | 4.5±1.5a | 3.4 ± 1.3b | 3.8±1.0ab |