Skip to main content

Table 2 Hemodynamic parameters

From: Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury

 

Condition

Wild type

Ob/ob

DKO

  

Sham

IR

Sham

IR

Sham

IR

Heart rate (bpm)

Untreated

575 ± 40

560±62

526 ± 44a

540±41

523 ± 29a

513±38

 

Diet

  

504 ± 30a

500 ± 31

503 ± 34a

516±51

 

ACE-I

548 ± 33

524 ± 36

505 ± 29

492±33

499 ± 51

509±68

Stroke volume (μl)

Untreated

16.2 ± 5.3

6.8±3.2c

14.8 ± 3.1

12.0±4.3a

10.1 ± 5.1a

9.6±4.1

 

Diet

  

13.6 ± 6.0

14.2±7.0a

11.8 ± 5.1

12.7±6.1a

 

ACE-I

16.5 ± 4.9

8.1 ± 1.6c

14.0 ± 3.2

12.6±4.2a

15.1 ± 6.1

12.4±3.0a

Stroke work (mmHg*μl)

Untreated

1256 ± 328

263±167c

835 ± 189a

509±181ac

606 ± 269a

409±199

 

Diet

  

804 ± 546

667±336a

627 ± 272a

676±332a

 

ACE-I

877 ± 399

369 ± 158c

788 ± 251

581±230

780 ± 408

563±170

P sys (mmHg)

Untreated

80.5 ± 18.2

55.1±10.6c

68.7 ± 7.5

62.5±2.7

69.5 ± 11.1

62.7±10.6

 

Diet

  

68.4 ± 10.8

60.4±5.9

67.1 ± 12.6

65.0±5.5a

 

ACE-I

62.9 ± 11.9

61.9 ± 19.9

67.9 ± 6.9

59.2±7.5c

61.4 ± 6.2

56.1±8.1d

P ed (mmHg)

Untreated

3.0 ± 0.7

2.9±1.2

3.6 ± 0.7

6.6±3.3ac

4.8 ± 2.3a

6.6±2.4a

 

Diet

  

3.0 ± 1.1

4.3±1.2a

3.8 ± 1.3

4.3±1.5ab

 

ACE-I

3.6 ± 2.0

2.9 ± 2.3

4.5 ± 0.9d

5.0±1.5

3.7 ± 0.9

3.4±1.5b

PRSW (mmHg)

Untreated

88.8 ± 5.5

61.5 ± 11.6c

64 ± 2.6a

48.5 ± 3.3ac

57.1 ± 4.6ae

46.2 ± 8.8ac

 

Diet

  

65.4 ± 1.9a

51 ± 1.9ac

58 ± 2.8ae

49.7 ± 3ac

 

ACE-I

87.4 ± 4.4

60.2 ± 6.4c

71.8 ± 3.2abd

52.1 ± 3.4ac

66.3 ± 5abde

51.2 ± 3.4ac

E es (mmHg/μl)

Untreated

8.3 ± 2.5

6.4±1.5

5.1 ± 0.4a

4.7±1.5

6.5 ± 2.4

4.5±0.8a

 

Diet

  

6.6 ± 2.1

4.5±1.1ac

5.1 ± 1.2a

5.3±1.2

 

ACE-I

6.0 ± 1.0

6.8 ± 2.0

5.5 ± 1.7

4.6±1.7

5.6 ± 1.3

4.4±1.3a

Tau (ms)

Untreated

6.3 ± 1.2

7.6±2.2

6.2 ± 0.5

6.4±1.0

6.9 ± 0.9

7.2±0.7

 

Diet

  

6.9 ± 0.5b

7.7±0.8bc

6.8 ± 0.6

7.3±1.2

 

ACE-I

6.6 ± 1.5

7.4 ± 1.5

8.0 ± 1.1bd

8.8±1.5b

7.4 ± 0.8

7.1±1.1e

EDPVR (mmHg/μl)

Untreated

0.2 ± 0.2

0.4±0.2

0.4 ± 0.3

0.5±0.3

0.6 ± 0.4a

0.3±0.1

 

Diet

  

0.2 ± 0.2

0.2±0.1

0.2 ± 0.2

0.2±0.1ab

 

ACE-I

0.2 ± 0.1

0.4 ± 0.3

0.4 ± 0.1

0.3±0.1

0.3 ± 0.1be

0.3±0.1d

E a (mmHg/μl)

Untreated

4.8 ± 1.5

8.1 ± 2.4c

4.0 ± 0.9

5.0±2.0a

6.8 ± 3.5

5.6±1.8a

 

Diet

  

4.9 ± 1.8

4.8±2.7a

5.2 ± 2.2

5.4±2.1a

 

ACE-I

3.3 ± 0.6b

6.9 ± 1.3c

4.6 ± 1.5

4.5±1.5a

3.4 ± 1.3b

3.8±1.0ab

  1. ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); Ea: arterial elastance; EDPVR: end-diastolic pressure-volume relationship; Ees: end-systolic elastance; IR: ischemia/reperfusion; Ped: end-diastolic pressure; Psys: systolic pressure “a” p < 0.05 versus WT same treatment, same condition (sham or IR); “b” p < 0.05 versus same untreated genotype, same condition (sham or IR); “c” p < 0.05 versus sham, same genotype, same treatment; “d” p < 0.05 versus diet, same genotype, same condition (sham or IR); “e” p < 0.05 versus ob/ob same treatment, same condition (sham or IR).