Angiotensin-converting enzyme inhibition and food restriction in diabetic mice do not correct the increased sensitivity for ischemia-reperfusion injury

Table 1 Metabolic parameters

Genotype	Age (weeks)	Treatment	Weight (g)	Heart weight / tibial lenght (mg/cm)	Glucose (mg/dl)	Cholesterol (mg/dl)	Triglycerides (mg/dl)
Wild type	12	Untreated	21.1 ± 3.1		56.2 ± 6.5	104 ± 70	115 ± 42
	24	Untreated	28.5 ± 4.4	74.1 ± 9.0	71.2 ± 11.8	76 ± 14	60 ± 14
Ob/ob	12	Untreated	49.5 ± 3.5^a		163 ± 73^a	125 ± 20	58 ± 11^a
	24	Untreated	62.7 ± 3.7^a	76.6 ± 7.7	166 ± 41^a	139 ± 35^a	68 ± 12
	24	Diet	38.5 ± 4.4^ac	71.8 ± 7.1^c	142 ± 63^a	74 ± 24^c	69 ± 15
	24	ACE-I	64.1 ± 9.4^ad	74.8 ± 9.1	84 ± 19^acd	145 ± 34^ad	76 ± 13^a
DKO	12	Untreated	47.0 ± 2.4^a		155 ± 47^a	912 ± 188^ab	591 ± 181^ab
	24	Untreated	59.4 ± 9.3^a	79.3 ± 13.4	152 ± 108^a	749 ± 114^ab	245 ± 80^ab
	24	Diet	38.2 ± 3.6^ac	68.0 ± 8.5^ac	141 ± 62^a	754 ± 123^ab	252 ± 110^ab
	24	ACE-I	64.0 ± 8.0^ad	70.3 ± 7.2^c	124 ± 36^ab	658 ± 166^ab	202 ± 67^ab

^“a” p < 0.05 versus WT, same age, untreated; ^“b”p < 0.05 versus ob/ob, same age, same treatment; ^“c” p < 0.05 versus same untreated genotype , same age; ^“d” p < 0.05 versus diet, same genotype, same age.

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