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Table 5 Changes in IVUS parameters in patients stratified according to HbA1c at baseline

From: High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)

 

HbA1c <6.5% (n = 86)

HbA1c ≥6.5% (n = 40)

 

Baseline

Follow-up

Actual change

% change

Baseline

Follow-up

Actual change

% change

Volume (mm3)

        

Plaque

71.0 ± 39.9

64.7 ± 34.7

−6.3 ± 12.3***

−6.8 ± 13.9***

74.3 ± 34.2

71.4 ± 32.3

−2.9 ± 11.4

−1.3 ± 13.8

Lumen

80.3 ± 41.9

82.4 ± 39.8

2.1 ± 11.3

5.6 ± 15.3**

73.9 ± 36.2

80 ± 38.7

6.1 ± 15.6*

10.8 ± 15.8**

Vessel

151.4 ± 75.8

147.1 ± 69

−4.3 ± 18.8*

−0.8 ± 10.7

148.2 ± 65.2

151.4 ± 64.6

3.2 ± 20.5

4.2 ± 13.1*

Area (mm2)

        

Plaque

8.6 ± 3.7

6.4 ± 3.1

−2.2 ± 2.1***

−24.4 ± 20.5

9.5 ± 3.1

7.9 ± 2.7

−1.7 ± 1.9***

−16.4 ± 17.9

Lumen

6.0 ± 2.8

6.9 ± 3.2

1.0 ± 1.6***

20.2 ± 29.5

6.2 ± 2.4

7.4 ± 3

1.2 ± 1.6***

21.8 ± 26.4

Vessel

14.6 ± 5.7

13.4 ± 5.2

−1.2 ± 2.3***

−7.6 ± 14.4

15.7 ± 4.6

15.3 ± 4.5

−0.5 ± 2.2

−2.0 ± 14.6

  1. Data are means ± SD.
  2. *p < 0.05, **p < 0.01, ***p < 0.0001 vs baseline; p < 0.05 vs patients with HbA1c <6.5%.
  3. IVUS, intravascular ultrasound.