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Table 5 Changes in IVUS parameters in patients stratified according to HbA1c at baseline

From: High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)

  HbA1c <6.5% (n = 86) HbA1c ≥6.5% (n = 40)
  Baseline Follow-up Actual change % change Baseline Follow-up Actual change % change
Volume (mm3)         
Plaque 71.0 ± 39.9 64.7 ± 34.7 −6.3 ± 12.3*** −6.8 ± 13.9*** 74.3 ± 34.2 71.4 ± 32.3 −2.9 ± 11.4 −1.3 ± 13.8
Lumen 80.3 ± 41.9 82.4 ± 39.8 2.1 ± 11.3 5.6 ± 15.3** 73.9 ± 36.2 80 ± 38.7 6.1 ± 15.6* 10.8 ± 15.8**
Vessel 151.4 ± 75.8 147.1 ± 69 −4.3 ± 18.8* −0.8 ± 10.7 148.2 ± 65.2 151.4 ± 64.6 3.2 ± 20.5 4.2 ± 13.1*
Area (mm2)         
Plaque 8.6 ± 3.7 6.4 ± 3.1 −2.2 ± 2.1*** −24.4 ± 20.5 9.5 ± 3.1 7.9 ± 2.7 −1.7 ± 1.9*** −16.4 ± 17.9
Lumen 6.0 ± 2.8 6.9 ± 3.2 1.0 ± 1.6*** 20.2 ± 29.5 6.2 ± 2.4 7.4 ± 3 1.2 ± 1.6*** 21.8 ± 26.4
Vessel 14.6 ± 5.7 13.4 ± 5.2 −1.2 ± 2.3*** −7.6 ± 14.4 15.7 ± 4.6 15.3 ± 4.5 −0.5 ± 2.2 −2.0 ± 14.6
  1. Data are means ± SD.
  2. *p < 0.05, **p < 0.01, ***p < 0.0001 vs baseline; p < 0.05 vs patients with HbA1c <6.5%.
  3. IVUS, intravascular ultrasound.