Skip to main content
Figure 4 | Cardiovascular Diabetology

Figure 4

From: Comparative vascular responses three months after paclitaxel and everolimus-eluting stent implantation in streptozotocin-induced diabetic porcine coronary arteries

Figure 4

Effects of paclitaxel and everolimus on caspase-3 activity in EC. EC were cultured in vitro under hyperglycemic conditions (42 mM) and allowed to grow to 80% confluence. Cells were then treated with growth media alone (control), or everolimus or paclitaxel (10-5 M, 10-7 M) for 24 hours. A caspase-3 fluorescent assay kit was used to quantify caspase-3 activity. Data expressed as fold change relative to control (mean ± standard deviation, n = 3). Paclitaxel increased EC caspase-3 activity in a dose-dependent manner while everolimus had no effect. * p < 0.05 vs. control

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840