Diabetes-induced left ventricular dysfunction were improved by ALA treatment. Cardiac dysfunction were evaluated by measuring (A) heart rate (HR), (B) left ventricular end-diastolic pressure (LVEDP), (C) maximum rate of fall of left ventricle pressure (-dP/dtmax), (D) left ventricular end-systolic pressure (LVSP), (E) maximum rate of rise of left ventricle pressure (+dP/dtmax). Eleven weeks of STZ-induced diabetes was associated with decrease in HR, LVSP and ± dp/dtmax and an increase in LVEDP, which were significantly improved by ALA treatment for 11 weeks. Results are presented as mean values ± standard deviation. *p < 0.05 vs Control group, #p < 0.05 vs. STZ group, n = 8 per group.