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Table 4 Effect of hyperglycemia on cardioprotection by pre- and post-conditioning

From: Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Species

Duration of Blood sugar

PC stimuli

First author

Journal

 

hyperglycemia

(mg/dl)

   

Hyperglycemia

Preserved protection

PC

Dog

before I

397

Diazoxide 5.0 mg/kg

Kersten

Am J Physiol 2001

Dog

before I

291

Isoflurane 1.0 MAC

Kehl

Anesthesiology 2002

Rat (SD)

before and during I

360

Fasudil 0.5 mg/kg

Ichinomiya

Cardiovasc Diabetol 2012

Rat (Wistar)

before and during I

446

Sevoflurane 1.0 MAC + CysA 5 mg/kg

Huhn

Br J Anaesth 2008

Rat (Wistar)

before and during I

343, 447

MIL 30 μg/kg, LEVO 100 μg/kg

Matsumoto

Cardiovasc Diabetol 2012

Impaired protection

PC

     

Dog

before I

296

4x 5I5R

Kersten

Am J Physiol 1998

Dog

before I

329

Diazoxide 2.5 mg/kg

Kersten

Am J Physiol 2001

Dog

before I

581, 558

Isoflurane 0.5, 1.0 MAC

Kehl

Anesthesiology 2002

Dog

before I

293

4x 5I5R

Gu

Anesthesiology 2008

Rabbit (NZ white)

before I

281

Isoflurane 1.0 MAC

Amour

Anesthesiology 2010

Rat (Wistar)

before I or during I

>400

Desflurane 1.0 MAC

Weber

Eur J Pharmacol 2008

PostC

     

Rabbit (NZ white)

before and during I

353

Isoflurane 1.0 MAC

Raphael

J Cardiovasc Pharmacol 2010

Rat (SD)

before and during I

360

Diazoxide 10 mg/kg, Fasudil 0.15 mg/kg

Ichinomiya

Cardiovasc Diabetol 2012

Rat (Wistar)

before and during I

445, 441

Sevoflurane 1.0 MAC, CysA 5 mg/kg

Huhn

Br J Anaesth 2008

Metabolic syndrome

Impaired protection

PostC

Rat (WOKW)

(28 w old)

105

3x 30sI30sR

Wagner

J Cardiovasc Pharmacol 2008

  1. NZ New Zealand, SD Sprague–Dawley, WOKW Wistar-Ottawa-Karlsburg W, before I before ischemia, during I during ischemia, MAC minimal alveolar concentration, CysA cyclosporine A, MIL milrinone, LEVO levosimendan, 5I5R 5-min ischemia/5-min reperfusion, 30sR30sI 30-second reperfusion/30-second ischemia.