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Table 4 Effect of hyperglycemia on cardioprotection by pre- and post-conditioning

From: Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Species Duration of Blood sugar PC stimuli First author Journal
  hyperglycemia (mg/dl)    
Hyperglycemia
Preserved protection
PC
Dog before I 397 Diazoxide 5.0 mg/kg Kersten Am J Physiol 2001
Dog before I 291 Isoflurane 1.0 MAC Kehl Anesthesiology 2002
Rat (SD) before and during I 360 Fasudil 0.5 mg/kg Ichinomiya Cardiovasc Diabetol 2012
Rat (Wistar) before and during I 446 Sevoflurane 1.0 MAC + CysA 5 mg/kg Huhn Br J Anaesth 2008
Rat (Wistar) before and during I 343, 447 MIL 30 μg/kg, LEVO 100 μg/kg Matsumoto Cardiovasc Diabetol 2012
Impaired protection
PC      
Dog before I 296 4x 5I5R Kersten Am J Physiol 1998
Dog before I 329 Diazoxide 2.5 mg/kg Kersten Am J Physiol 2001
Dog before I 581, 558 Isoflurane 0.5, 1.0 MAC Kehl Anesthesiology 2002
Dog before I 293 4x 5I5R Gu Anesthesiology 2008
Rabbit (NZ white) before I 281 Isoflurane 1.0 MAC Amour Anesthesiology 2010
Rat (Wistar) before I or during I >400 Desflurane 1.0 MAC Weber Eur J Pharmacol 2008
PostC      
Rabbit (NZ white) before and during I 353 Isoflurane 1.0 MAC Raphael J Cardiovasc Pharmacol 2010
Rat (SD) before and during I 360 Diazoxide 10 mg/kg, Fasudil 0.15 mg/kg Ichinomiya Cardiovasc Diabetol 2012
Rat (Wistar) before and during I 445, 441 Sevoflurane 1.0 MAC, CysA 5 mg/kg Huhn Br J Anaesth 2008
Metabolic syndrome
Impaired protection
PostC
Rat (WOKW) (28 w old) 105 3x 30sI30sR Wagner J Cardiovasc Pharmacol 2008
  1. NZ New Zealand, SD Sprague–Dawley, WOKW Wistar-Ottawa-Karlsburg W, before I before ischemia, during I during ischemia, MAC minimal alveolar concentration, CysA cyclosporine A, MIL milrinone, LEVO levosimendan, 5I5R 5-min ischemia/5-min reperfusion, 30sR30sI 30-second reperfusion/30-second ischemia.