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Table 3 Effect of diabetes mellitus on cardioprotection by pre- and post-conditioning

From: Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Species DM PC stimuli First author Journal
  type duration    
Preserved protection
PC
Rat (SD) 1 4 w 3x 5I5R Shi-Ting Biomed Pharmacother 2010
Rat (Wistar) 2 11-12 m 3x 5I5R Liu Circulation 1993
Rat (Wistar) 1 6 w LiCl 20 mM, IND 1 μM, SB 3 μM Yadav Mol Cell Biochem 2010
Rat (Zucker diabetic fatty) 2 (10-12 w old) Rosiglitazone 3 mg/kg for 1 week Yue Diabetes 2005
Rat (OLETF) 2 (25-30 w old) SB 1.2 mg/kg Miki Diabetes 2009
Rat (Goto-Kakizaki) 2   3x 5I10R Tsang Diabetes 2005
Rat (Goto-Kakizaki) 2 (12 w old) WY 1 mg/kg Bulhak Am J Physiol 2009
Rat (Goto-Kakizaki) 2   olprinone 10 μg/kg Matsumoto Cardiovasc Drug Ther 2009
Mice (ob/ob) 2 (8-10 w old) Metformin 125 μg/kg Calvert Diabetes 2008
Mice (KK-Ay) 2 (6 w old) Pioglitazone 25 mg/kg for 2 week Honda J Mol Cell Cardiol 2008
PostC      
Rat (SD) 1 2 w SB 0.6 mg/kg Gross Diabetes 2007
Rat (Wistar) 1 4 w SB 3 μM Ghaboura Basic Res Cardiol 2011
Rat (OLETF) 2 (25-30 w old) BIO 0.08 mg/kg Hotta Circ Res 2010
Rat (Goto-Kakizaki) 2   Metformin 50 μM Bhamra Basic Res Cardiol 2008
Mice (ob/ob) 2 (8-10 w old) Metformin 125 μg/kg Calvert Diabetes 2008
Impaired protection
PC
Dog 1 3 w 4x 5I5R Kersten Am J Physiol 2000
Dog 1 3 w Diazoxide 2.5 mg/kg Kersten Am J Physiol 2001
Rabbit (NZ) 1 4-5 w 3x 2I2R Nieszner Exp Clin Endocrinol Diabetes 2002
Rat (SD) 1 8 w 3x 5I5R Wang Biomedicine Aging Pathol 2011
Rat (Wistar) 1 6 w 5I5R Galagudza Neurosci Behav Physiol 2007
Rat (Wistar) 1 6 w 4x 5I5R Yadav Mol Cell Biochem 2010
Rat (Wistar) 2 10-12 w Metformin 200 mg/kg for 3 days Kravchuk Exp Diabetes Res 2011
Rat (Zucker obese) 2 (10-12 w old) 5I5R, Diazoxide 10 mg/kg Katakam Am J Physiol 2007
Rat (Zucker diabetic fatty) 2 (16 w old) 4x 2I3R Kristiansen Diabetologia 2004
Rat (OLETF) 2 (25-30 w old) EPO 5000 U/kg Miki Diabetes 2009
Rat (OLETF) 2 (25-30 w old) EPO 5000 U/kg, DADLE 1 mg/kg Hotta Circ Res 2010
Rat (Goto-Kakizaki) 2 (16 w old) 4x 2I3R Kristiansen Diabetologia 2004
Rat (Goto-Kakizaki) 2   5I10R, 2x 5I10R Tsang Diabetes 2005
Rat (Goto-Kakizaki) 2 (16-18 w old) EPO 5000 U/kg Miki Diabetes 2009
Rat (Goto-Kakizaki) 2   isoflurane 1.0% Matsumoto Cardiovasc Drug Ther 2009
PostC
Rat (SD) 1 2 w Morphine 0.3 mg/kg Gross Diabetes 2007
Rat (SD) 1 4-5 w 3x 20sR20sI, sevoflurane 1.0 MAC Drenger Anesthesiology 2011
Rat (Wistar) 1 4 w Darbopoetin alpha 5 μg/kg Ghaboura Basic Res Cardiol 2011
Mice 1 2 w 3x 10sR10sI, 6x 10sR10sI Przyklenk Antioxid Redox Signal 2011
Mice (ob/ob) 2 (8-10 w old) 6x 10sR10sI Bouhidel Am J Physiol 2008
Mice (ob/ob) 2 (12-14 w old) 3x 10sR10sI, 6x 10sR10sI Przyklenk Antioxid Redox Signal 2011
Mice (ob/ob) 2 (10-12 w old) 6x 10sR10sI Zhu J Cell Mol Med 2011
Mice (KK-Ay) 2 (6 w old) Pioglitazone 25 mg/kg Honda J Mol Cell Cardiol 2008
Late PC
Rabbit (NZ white) 1 5-6 w 5I24hR Ebel Pflugers Arch 2003
  1. IND indirubin-3 monooxime (a GSK-3β inhibitor), SB SB216763 (a GSK-3β inhibitor), WY 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (a PPAR-α agonist), BIO 6-bromo-indirubin-3'-oxime (a GSK3β inhibitor), EPO erythropoietin, DADLE [D-Ala2, D-Leu5]-enkephalin acetate (a δ-opioid receptor agonist), 5I5R 5-min ischemia/5-min reperfusion, 5I24hR 5-min ischemia/24-hour reperfusion, 10sR10sI 10-second reperfusion/10-second ischemia, MAC minimal alveolar concentration, w weeks, m months.