Table 3 Effect of diabetes mellitus on cardioprotection by pre- and post-conditioning
Species | DM | PC stimuli | First author | Journal | |
|---|---|---|---|---|---|
| Â | type | duration | Â | Â | Â |
Preserved protection | |||||
PC | |||||
Rat (SD) | 1 | 4 w | 3x 5I5R | Shi-Ting | Biomed Pharmacother 2010 |
Rat (Wistar) | 2 | 11-12 m | 3x 5I5R | Liu | Circulation 1993 |
Rat (Wistar) | 1 | 6 w | LiCl 20 mM, IND 1 μM, SB 3 μM | Yadav | Mol Cell Biochem 2010 |
Rat (Zucker diabetic fatty) | 2 | (10-12 w old) | Rosiglitazone 3 mg/kg for 1 week | Yue | Diabetes 2005 |
Rat (OLETF) | 2 | (25-30 w old) | SB 1.2 mg/kg | Miki | Diabetes 2009 |
Rat (Goto-Kakizaki) | 2 | Â | 3x 5I10R | Tsang | Diabetes 2005 |
Rat (Goto-Kakizaki) | 2 | (12 w old) | WY 1 mg/kg | Bulhak | Am J Physiol 2009 |
Rat (Goto-Kakizaki) | 2 |  | olprinone 10 μg/kg | Matsumoto | Cardiovasc Drug Ther 2009 |
Mice (ob/ob) | 2 | (8-10 w old) | Metformin 125 μg/kg | Calvert | Diabetes 2008 |
Mice (KK-Ay) | 2 | (6 w old) | Pioglitazone 25 mg/kg for 2 week | Honda | J Mol Cell Cardiol 2008 |
PostC | Â | Â | Â | Â | Â |
Rat (SD) | 1 | 2 w | SB 0.6 mg/kg | Gross | Diabetes 2007 |
Rat (Wistar) | 1 | 4 w | SB 3 μM | Ghaboura | Basic Res Cardiol 2011 |
Rat (OLETF) | 2 | (25-30 w old) | BIO 0.08 mg/kg | Hotta | Circ Res 2010 |
Rat (Goto-Kakizaki) | 2 |  | Metformin 50 μM | Bhamra | Basic Res Cardiol 2008 |
Mice (ob/ob) | 2 | (8-10 w old) | Metformin 125 μg/kg | Calvert | Diabetes 2008 |
Impaired protection | |||||
PC | |||||
Dog | 1 | 3 w | 4x 5I5R | Kersten | Am J Physiol 2000 |
Dog | 1 | 3 w | Diazoxide 2.5 mg/kg | Kersten | Am J Physiol 2001 |
Rabbit (NZ) | 1 | 4-5 w | 3x 2I2R | Nieszner | Exp Clin Endocrinol Diabetes 2002 |
Rat (SD) | 1 | 8 w | 3x 5I5R | Wang | Biomedicine Aging Pathol 2011 |
Rat (Wistar) | 1 | 6 w | 5I5R | Galagudza | Neurosci Behav Physiol 2007 |
Rat (Wistar) | 1 | 6 w | 4x 5I5R | Yadav | Mol Cell Biochem 2010 |
Rat (Wistar) | 2 | 10-12 w | Metformin 200 mg/kg for 3 days | Kravchuk | Exp Diabetes Res 2011 |
Rat (Zucker obese) | 2 | (10-12 w old) | 5I5R, Diazoxide 10 mg/kg | Katakam | Am J Physiol 2007 |
Rat (Zucker diabetic fatty) | 2 | (16 w old) | 4x 2I3R | Kristiansen | Diabetologia 2004 |
Rat (OLETF) | 2 | (25-30 w old) | EPO 5000 U/kg | Miki | Diabetes 2009 |
Rat (OLETF) | 2 | (25-30 w old) | EPO 5000 U/kg, DADLE 1 mg/kg | Hotta | Circ Res 2010 |
Rat (Goto-Kakizaki) | 2 | (16 w old) | 4x 2I3R | Kristiansen | Diabetologia 2004 |
Rat (Goto-Kakizaki) | 2 | Â | 5I10R, 2x 5I10R | Tsang | Diabetes 2005 |
Rat (Goto-Kakizaki) | 2 | (16-18 w old) | EPO 5000 U/kg | Miki | Diabetes 2009 |
Rat (Goto-Kakizaki) | 2 | Â | isoflurane 1.0% | Matsumoto | Cardiovasc Drug Ther 2009 |
PostC | |||||
Rat (SD) | 1 | 2 w | Morphine 0.3 mg/kg | Gross | Diabetes 2007 |
Rat (SD) | 1 | 4-5 w | 3x 20sR20sI, sevoflurane 1.0 MAC | Drenger | Anesthesiology 2011 |
Rat (Wistar) | 1 | 4 w | Darbopoetin alpha 5 μg/kg | Ghaboura | Basic Res Cardiol 2011 |
Mice | 1 | 2 w | 3x 10sR10sI, 6x 10sR10sI | Przyklenk | Antioxid Redox Signal 2011 |
Mice (ob/ob) | 2 | (8-10 w old) | 6x 10sR10sI | Bouhidel | Am J Physiol 2008 |
Mice (ob/ob) | 2 | (12-14 w old) | 3x 10sR10sI, 6x 10sR10sI | Przyklenk | Antioxid Redox Signal 2011 |
Mice (ob/ob) | 2 | (10-12 w old) | 6x 10sR10sI | Zhu | J Cell Mol Med 2011 |
Mice (KK-Ay) | 2 | (6 w old) | Pioglitazone 25 mg/kg | Honda | J Mol Cell Cardiol 2008 |
Late PC | |||||
Rabbit (NZ white) | 1 | 5-6 w | 5I24hR | Ebel | Pflugers Arch 2003 |