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Table 1 Effect of diabetes mellitus on infarct size

From: Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Species DM   Index ischemia   First author Journal
  type duration min type   
Infarct size enlargement
Dog 2 75 d 120 regional, vivo Forrat Cardiovasc Res 1993
Rat (SD) 1 8 d 25 regional, vivo Marfella Diabetologia 2002
Rat (SD) 1 8 d 25 regional, vivo Di Filippo Diabetes 2005
Rat (SD) 1 30 d 30 global, vitro Thirunavukkarasu Free Radic Biol Med 2007
Rat (Wistar) 1 2 w 30 regional, vivo Xiao J Pharmacol Exp Ther 2004
Rat (Zucker obese) 2   30 regional, vivo Jordan J Pharmacol Exp Ther 2003
Rat (Zucker obese) 2 (10-12 w old) 30 regional, vivo Katakam Am J Physiol 2007
Rat (Zucker diabetic fatty) 2 (10-12 w old) 30 regional, vivo Yue Diabetes 2005
Rat (Zucker diabetic fatty) 2 (12-16 w old) 30 regional, vivo La Bonte Am J Physiol 2008
Rat (OLETF) 2 (25-30 w old) 20 regional, vivo Miki Diabetes 2009
Rat (OLETF) 2 (25-30 w old) 20 regional, vivo Hotta Circ Res 2010
Mice 1 8 d 25 regional, vivo Marfella Diabetes 2004
Mice 1 4 w 60 regional, vivo Liu Diabetes 2005
Mice (ob/ob) 2 (8-10 w old) 30 regional, vivo Bouhidel Am J Physiol 2008
Mice (ob/ob) 2 (8-10 w old) 30 regional, vivo Calvert Diabetes 2008
Mice (ob/ob) 2 (10-12 w old) 30 regional, vivo Zhu J Cell Mol Med 2011
Mice (KK-Ay) 2 (6 w old) 40 regional, vivo Honda J Mol Cell Cardiol 2008
Infarct size reduction
Rabbit (NZ) 1 8 w 30 regional, vivo Hadour J Mol Cell Cardiol 1998
Rat (SD) 1 2 w 30 regional, vivo Ma N-S Arch Pharmacol 2006
Rat (Wistar) 2 11-12 m 30, 45 regional, vivo Liu Circulation 1993
Rat (Wistar) 1 1 w 30 regional, vivo Ravingerová Mol Cell Biochem 2003
Rat (Wistar) 1 4 w 30 regional, vivo Xu Exp Mol Pathol 2004
Rat (Wistar) 1 6 w 30 regional, vivo Galagudza Neurosci Behav Physiol 2007
Rat (Wistar) 2 10-12 w 30 global, vitro Kravchuk Exp Diabetes Res 2011
Rat (Wistar-Kyoto) 2 9 m 40 regional, vitro Mozaffari Hypertension 2003
Rat (Zucker diabetic fatty) 2 (16 w old) 50 regional, vitro Kristiansen Diabetologia 2004
Rat (Goto-Kakizaki) 2 (16 w old) 50 regional, vitro Kristiansen Diabetologia 2004
Rat (Goto-Kakizaki) 2 (16 w old) 45 regional, vitro Kristiansen Diabetologia 2011
No change in infarct size
Dog 1 3 w 60 regional, vivo Kersten Am J Physiol 2000
Dog 1 3 w 60 regional, vivo Kersten Am J Physiol 2001
Rabbit (NZ) 1 10-16 w 30 regional, vivo Vogel Circ Res 1988
Rabbit (NZ) 1 4-5 w 60 regional, vivo Nieszner Exp Clin Endocrinol Diabetes 2002
Rabbit (NZ white) 1 5-6 w 30 regional, vivo Ebel Pflügers Arch 2003
Rat (SD) 1 6 w 30 regional, vivo Ma N-S Arch Pharmacol 2006
Rat (SD) 1 2 w 30 regional, vivo Gross Diabetes 2007
Rat (SD) 1 4 w, 8 w 30 global, vitro Shi-Ting Biomed Pharmacother 2010
Rat (SD) 1 4-5 w 30 regional, vivo Drenger Anesthesiology 2011
Rat (SD) 1 4 w 30 global, vitro Okazaki J Mol Cell Cardiol 2011
Rat (Wistar) 1 8 w 30 regional, vitro Joyeux Cardiovasc Res 1999
Rat (Wistar) 1 8 w 30 regional, vivo Ravingerová Mol Cell Biochem 2003
Rat (Wistar) 1 20 w 30 regional, vivo Xu Exp Mol Pathol 2004
Rat (Wistar) 1 4 w 25 global, vitro Ghaboura Basic Res Cardiol 2011
Rat (Goto-Kakizaki) 2   35 regional, vitro Tsang Diabetes 2005
Rat (Goto-Kakizaki) 2   35 regional, vitro Bhamra Basic Res Cardiol 2008
Rat (Goto-Kakizaki) 2 (12 w old) 35 regional, vivo Bulhak Am J Physiol 2009
Rat (Goto-Kakizaki) 2   30 regional, vivo Matsumoto Cardiovasc Drug Ther 2009
Mice 1 2 w 30 global, vitro Przyklenk Antioxid Redox Signal 2011
Mice (ob/ob) 2 (12-14 w old) 30 global, vitro Przyklenk Antioxid Redox Signal 2011
  1. SD, Sprague–Dawley; NZ, New Zealand; OLETF, Otsuka Long-Evans-Tokushima fatty; d, days; w, weeks.