ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion

Table 1 Clinical and biochemical characteristics of the study population

Parameter	Control (n = 10)	Fasudil (n = 10)	P -Value
Age, years	69 ± 9.4	71 ± 7.4	0.768
Male, n (%)	7 (70%)	6 (60%)	0.595
BMI, kg/m²	23.7 ± 3.0	25.3 ± 2.6	0.414
Smoking, n (%)	7 (70%)	8 (80%)	0.722
Hypertension, n (%)	6 (60%)	4 (40%)	0.357
Hyperlipidemia, n (%)	3 (30%)	2 (20%)	0.722
SBP, mmHg	138 ± 16.6	150.0 ± 25.5	0.427
DBP, mmHg	79 ± 8.5	86 ± 15.2	0.454
Total cholesterol, mmol/L	4.33 ± 0.87	4.48 ± 2.33	0.909
HDL-C, mmol/L	0.95 ± 0.27	1.09 ± 0.39	0.599
LDL-C, mmol/L	2.72 ± 0.49	2.84 ± 1.77	0.900
Triglycerides, mmol/L	1.46 ± 0.66	1.41 ± 0.39	0.906
FPG, mmol/L	5.58 ± 0.75	6.38 ± 1.87	0.467
hsCRP, mg/L	6.85 ± 4.08	6.37 ± 4.78	0.437
Alanine aminotransferase, U/L	29.5 ± 13.31	26.5 ± 5.69	0.865
BUN, mmol/L	6.30 ± 0.53	5.90 ± 2.44	0.756

Continuous variables were described as means ± SD; categorical variables were presented as frequencies. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; n, number of patients; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; FPG, fasting plasma glucose; BUN, blood urine nitrogen; hsCRP, high-sensitivity CRP.

ISSN: 1475-2840