TY - JOUR AU - Li, Hailing AU - Peng, Wenhui AU - Jian, Weixia AU - Li, Yuanmin AU - Li, Qi AU - Li, Weiming AU - Xu, Yawei PY - 2012 DA - 2012/06/13 TI - ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion JO - Cardiovascular Diabetology SP - 65 VL - 11 IS - 1 AB - Previous studies suggested that the RhoA/ROCK pathway may contribute to vascular complications in diabetes. The present study was designed to investigate whether ROCK inhibitor fasudil could prevent high glucose-induced monocyte-endothelial cells adhesion, and whether this was related to fasudil effects on vascular endothelial cell expression of chemotactic factors, vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1). SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-11-65 DO - 10.1186/1475-2840-11-65 ID - Li2012 ER -