Table 2 Changes in hemodynamic, arterial stiffness and metabolic parameters in metformin treated patients during 12 months follow up
Variable | Metformin treated patients | ||||
|---|---|---|---|---|---|
Baseline | 4 month | p-valueV1 vs V2 | 12 month | p-valueV1 vs V3 | |
Systolic BP (mm/Hg) | 139.0 ± 17.9 | 137.2 ± 20.1 | 0.565 | 131.5 ± 14.0 | 0.060 |
Diastolic BP (mm/Hg) | 80.6 ± 9.2 | 78.4 ± 9.0 | 0.403 | 80.9 ± 8.8 | 0.921 |
Aortic AP (mm/Hg) | 15.6 ± 9.1 | 11.4 ± 7.6 | 0.001 | 12.8 ± 5.2 | 0.257 |
AI (%) | 31.4 ± 10.2 | 23.1 ± 8.5 | <0.0001 | 24.8 ± 7.9 | 0.009 |
Total Cholesterol (mg/dl) | 179.3 ± 40.3 | 176.7 ± 32.2 | 0.722 | 178.2 ± 25 | 0.985 |
Triglycerides (mg/dl) | 195.4 ± 119.1 | 157.9 ± 97.4 | 0.033 | 195.7 ± 149.7 | 0.574 |
HDL-cholesterol (mg/dl) | 41.3 ± 12.2 | 45.7 ± 15.0 | 0.001 | 42.2 ± 11.6 | 0.768 |
LDL Cholesterol (mg/dl) | 103.5 ± 37.3 | 103.7 ± 22.1 | 0.979 | 111.8 ± 23.8 | 0.286 |
ALP (U/l) | 66.5 ± 17.8 | 61.1 ± 15.6 | 0.007 | 65.2 ± 19.7 | 0.452 |
ALT (U/l) | 38.5 ± 31.7 | 29.3 ± 16.2 | 0.092 | 39.2 ± 21.8 | 0.838 |
AST (U/l) | 29.0 ± 18.0 | 25.4 ± 9.7 | 0.300 | 30.6 ± 11.6 | 0.991 |
hs-CRP (mg/dl) | 1.0 ± 1.1 | 0.5 ± 0.4 | 0.081 | 0.7 ± 0.9 | 0.448 |
Fasting glucose (mg/dl) | 135.0 ± 52.8 | 115.8 ± 27.0 | 0.036 | 125.7 ± 54 | 0.185 |
Adiponectin (ng/ml) | 5661.8 ± 2820 | 6166.6 ± 3265 | 0.171 | 6102.4 ± 2139 | 0.746 |
HOMA-IR | 7.2 ± 6.3 | 7.3 ± 10.9 | 0.920 | 5.7 ± 6 | 0.042 |