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Table 4 Unadjusted and adjusted mean changes in laboratory parameters values during0020exposure period from baseline

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test

Unadjusted

Adjusted†

 

Mean

(95%CI)

p-value

Mean

(95%CI)

p-value

ΔTG (mmol/L)

CCB

-0.058

(-0.134, 0.017)

0.7509

-0.067

(-0.139, 0.006)

0.5062

ARB

-0.041

(-0.116, 0.035)

 

-0.032

(-0.105, 0.04)

 

ΔTC (mmol/L)

CCB

-0.119

(-0.182, -0.056)

0.4512

-0.123

(-0.185, -0.061)

0.5664

ARB

-0.153

(-0.217, -0.09)

 

-0.149

(-0.211, -0.087)

 

ΔBlood glucose (mmol/L)

CCB

-0.17

(-0.439, 0.099)

0.9651

-0.177

(-0.447, 0.093)

0.9085

ARB

-0.161

(-0.431, 0.108)

 

-0.154

(-0.424, 0.115)

 

ΔHbA1c (%)

CCB

-0.087

(-0.175, 0.002)

0.2669

-0.089

(-0.175, -0.003)

0.2887

ARB

-0.157

(-0.246, -0.069)

 

-0.155

(-0.241, -0.069)

 

ΔCreatinine (μmol/L)

CCB

1.575

(-0.59, 3.74)

0.5503

1.667

(-0.466, 3.801)

0.6275

ARB

2.508

(0.343, 4.673)

 

2.416

(0.282, 4.549)

 

ΔSodium (mmol/L)

CCB

-0.24

(-0.462, -0.017)

0.8194

-0.239

(-0.458, -0.019)

0.8275

ARB

-0.203

(-0.425, 0.019)

 

-0.204

(-0.424, 0.016)

 

ΔPotassium (mmol/L)

CCB

-0.005

(-0.037, 0.027)

0.0173 *

-0.005

(-0.037, 0.027)

0.0182 *

ARB

0.05

(0.018, 0.082)

 

0.05

(0.018, 0.081)

 

ΔALT (U/L)

CCB

-0.639

(-2.463, 1.185)

0.2966

-0.633

(-2.433, 1.167)

0.2871

ARB

-2.012

(-3.835, -0.188)

 

-2.018

(-3.818, -0.218)

 

ΔAST (U/L)

CCB

0.667

(-0.859, 2.193)

0.1633

0.664

(-0.847, 2.175)

0.1618

ARB

-0.867

(-2.393, 0.659)

 

-0.864

(-2.375, 0.647)

 

ΔGGT (U/L)

CCB

1.599

(-4.675, 7.873)

0.238

1.648

(-4.644, 7.939)

0.2319

ARB

-3.74

(-10.015, 2.534)

 

-3.789

(-10.081, 2.502)

 

ΔWBC (x109/L)

CCB

-0.057

(-0.185, 0.072)

0.6864

-0.048

(-0.176, 0.08)

0.8298

ARB

-0.019

(-0.148, 0.109)

 

-0.028

(-0.156, 0.099)

 

ΔRBC (x1012/L)

CCB

-0.032

(-0.058, -0.006)

0.0005 *

-0.032

(-0.058, -0.006)

0.0004 *

ARB

-0.097

(-0.123, -0.072)

 

-0.098

(-0.124, -0.072)

 

ΔPLT (x109/L)

CCB

5.03

(1.71, 8.35)

0.0825

5.057

(1.793, 8.321)

0.0743

ARB

0.872

(-2.448, 4.192)

 

0.845

(-2.419, 4.109)

 

ΔHemoglobin (g/L)

CCB

-1.722

(-2.542, -0.903)

0.0476 *

-1.721

(-2.538, -0.904)

0.047 *

ARB

-2.894

(-3.713, -2.074)

 

-2.895

(-3.712, -2.078)

 

ΔHematocrit (mmol/mol)

CCB

-0.003

(-0.005, -0.001)

0.0103 *

-0.003

(-0.005, -0.001)

0.0092 *

ARB

-0.007

(-0.01, -0.005)

 

-0.007

(-0.01, -0.005)

 
  1. Δ indicates mean change in laboratory test value between baseline and exposure period. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltransferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (ARB vs CCB). † Analyses were adjusted by covariates including age, sex, medical history and previous drugs.
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Cardiovascular Diabetology

ISSN: 1475-2840