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Table 4 Unadjusted and adjusted mean changes in laboratory parameters values during0020exposure period from baseline

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test Unadjusted Adjusted†
  Mean (95%CI) p-value Mean (95%CI) p-value
ΔTG (mmol/L)
CCB -0.058 (-0.134, 0.017) 0.7509 -0.067 (-0.139, 0.006) 0.5062
ARB -0.041 (-0.116, 0.035)   -0.032 (-0.105, 0.04)  
ΔTC (mmol/L)
CCB -0.119 (-0.182, -0.056) 0.4512 -0.123 (-0.185, -0.061) 0.5664
ARB -0.153 (-0.217, -0.09)   -0.149 (-0.211, -0.087)  
ΔBlood glucose (mmol/L)
CCB -0.17 (-0.439, 0.099) 0.9651 -0.177 (-0.447, 0.093) 0.9085
ARB -0.161 (-0.431, 0.108)   -0.154 (-0.424, 0.115)  
ΔHbA1c (%)
CCB -0.087 (-0.175, 0.002) 0.2669 -0.089 (-0.175, -0.003) 0.2887
ARB -0.157 (-0.246, -0.069)   -0.155 (-0.241, -0.069)  
ΔCreatinine (μmol/L)
CCB 1.575 (-0.59, 3.74) 0.5503 1.667 (-0.466, 3.801) 0.6275
ARB 2.508 (0.343, 4.673)   2.416 (0.282, 4.549)  
ΔSodium (mmol/L)
CCB -0.24 (-0.462, -0.017) 0.8194 -0.239 (-0.458, -0.019) 0.8275
ARB -0.203 (-0.425, 0.019)   -0.204 (-0.424, 0.016)  
ΔPotassium (mmol/L)
CCB -0.005 (-0.037, 0.027) 0.0173 * -0.005 (-0.037, 0.027) 0.0182 *
ARB 0.05 (0.018, 0.082)   0.05 (0.018, 0.081)  
ΔALT (U/L)
CCB -0.639 (-2.463, 1.185) 0.2966 -0.633 (-2.433, 1.167) 0.2871
ARB -2.012 (-3.835, -0.188)   -2.018 (-3.818, -0.218)  
ΔAST (U/L)
CCB 0.667 (-0.859, 2.193) 0.1633 0.664 (-0.847, 2.175) 0.1618
ARB -0.867 (-2.393, 0.659)   -0.864 (-2.375, 0.647)  
ΔGGT (U/L)
CCB 1.599 (-4.675, 7.873) 0.238 1.648 (-4.644, 7.939) 0.2319
ARB -3.74 (-10.015, 2.534)   -3.789 (-10.081, 2.502)  
ΔWBC (x109/L)
CCB -0.057 (-0.185, 0.072) 0.6864 -0.048 (-0.176, 0.08) 0.8298
ARB -0.019 (-0.148, 0.109)   -0.028 (-0.156, 0.099)  
ΔRBC (x1012/L)
CCB -0.032 (-0.058, -0.006) 0.0005 * -0.032 (-0.058, -0.006) 0.0004 *
ARB -0.097 (-0.123, -0.072)   -0.098 (-0.124, -0.072)  
ΔPLT (x109/L)
CCB 5.03 (1.71, 8.35) 0.0825 5.057 (1.793, 8.321) 0.0743
ARB 0.872 (-2.448, 4.192)   0.845 (-2.419, 4.109)  
ΔHemoglobin (g/L)
CCB -1.722 (-2.542, -0.903) 0.0476 * -1.721 (-2.538, -0.904) 0.047 *
ARB -2.894 (-3.713, -2.074)   -2.895 (-3.712, -2.078)  
ΔHematocrit (mmol/mol)
CCB -0.003 (-0.005, -0.001) 0.0103 * -0.003 (-0.005, -0.001) 0.0092 *
ARB -0.007 (-0.01, -0.005)   -0.007 (-0.01, -0.005)  
  1. Δ indicates mean change in laboratory test value between baseline and exposure period. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltransferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (ARB vs CCB). † Analyses were adjusted by covariates including age, sex, medical history and previous drugs.