|
Laboratory test
|
Unadjusted
|
Adjusted†
|
|---|
| |
Mean
|
(95%CI)
|
p-value
|
Mean
|
(95%CI)
|
p-value
|
|---|
|
ΔTG (mmol/L)
|
|
CCB
|
-0.058
|
(-0.134, 0.017)
|
0.7509
|
-0.067
|
(-0.139, 0.006)
|
0.5062
|
|
ARB
|
-0.041
|
(-0.116, 0.035)
| |
-0.032
|
(-0.105, 0.04)
| |
|
ΔTC (mmol/L)
|
|
CCB
|
-0.119
|
(-0.182, -0.056)
|
0.4512
|
-0.123
|
(-0.185, -0.061)
|
0.5664
|
|
ARB
|
-0.153
|
(-0.217, -0.09)
| |
-0.149
|
(-0.211, -0.087)
| |
|
ΔBlood glucose (mmol/L)
|
|
CCB
|
-0.17
|
(-0.439, 0.099)
|
0.9651
|
-0.177
|
(-0.447, 0.093)
|
0.9085
|
|
ARB
|
-0.161
|
(-0.431, 0.108)
| |
-0.154
|
(-0.424, 0.115)
| |
|
ΔHbA1c (%)
|
|
CCB
|
-0.087
|
(-0.175, 0.002)
|
0.2669
|
-0.089
|
(-0.175, -0.003)
|
0.2887
|
|
ARB
|
-0.157
|
(-0.246, -0.069)
| |
-0.155
|
(-0.241, -0.069)
| |
|
ΔCreatinine (μmol/L)
|
|
CCB
|
1.575
|
(-0.59, 3.74)
|
0.5503
|
1.667
|
(-0.466, 3.801)
|
0.6275
|
|
ARB
|
2.508
|
(0.343, 4.673)
| |
2.416
|
(0.282, 4.549)
| |
|
ΔSodium (mmol/L)
|
|
CCB
|
-0.24
|
(-0.462, -0.017)
|
0.8194
|
-0.239
|
(-0.458, -0.019)
|
0.8275
|
|
ARB
|
-0.203
|
(-0.425, 0.019)
| |
-0.204
|
(-0.424, 0.016)
| |
|
ΔPotassium (mmol/L)
|
|
CCB
|
-0.005
|
(-0.037, 0.027)
|
0.0173 *
|
-0.005
|
(-0.037, 0.027)
|
0.0182 *
|
|
ARB
|
0.05
|
(0.018, 0.082)
| |
0.05
|
(0.018, 0.081)
| |
|
ΔALT (U/L)
|
|
CCB
|
-0.639
|
(-2.463, 1.185)
|
0.2966
|
-0.633
|
(-2.433, 1.167)
|
0.2871
|
|
ARB
|
-2.012
|
(-3.835, -0.188)
| |
-2.018
|
(-3.818, -0.218)
| |
|
ΔAST (U/L)
|
|
CCB
|
0.667
|
(-0.859, 2.193)
|
0.1633
|
0.664
|
(-0.847, 2.175)
|
0.1618
|
|
ARB
|
-0.867
|
(-2.393, 0.659)
| |
-0.864
|
(-2.375, 0.647)
| |
|
ΔGGT (U/L)
|
|
CCB
|
1.599
|
(-4.675, 7.873)
|
0.238
|
1.648
|
(-4.644, 7.939)
|
0.2319
|
|
ARB
|
-3.74
|
(-10.015, 2.534)
| |
-3.789
|
(-10.081, 2.502)
| |
|
ΔWBC (x109/L)
|
|
CCB
|
-0.057
|
(-0.185, 0.072)
|
0.6864
|
-0.048
|
(-0.176, 0.08)
|
0.8298
|
|
ARB
|
-0.019
|
(-0.148, 0.109)
| |
-0.028
|
(-0.156, 0.099)
| |
|
ΔRBC (x1012/L)
|
|
CCB
|
-0.032
|
(-0.058, -0.006)
|
0.0005 *
|
-0.032
|
(-0.058, -0.006)
|
0.0004 *
|
|
ARB
|
-0.097
|
(-0.123, -0.072)
| |
-0.098
|
(-0.124, -0.072)
| |
|
ΔPLT (x109/L)
|
|
CCB
|
5.03
|
(1.71, 8.35)
|
0.0825
|
5.057
|
(1.793, 8.321)
|
0.0743
|
|
ARB
|
0.872
|
(-2.448, 4.192)
| |
0.845
|
(-2.419, 4.109)
| |
|
ΔHemoglobin (g/L)
|
|
CCB
|
-1.722
|
(-2.542, -0.903)
|
0.0476 *
|
-1.721
|
(-2.538, -0.904)
|
0.047 *
|
|
ARB
|
-2.894
|
(-3.713, -2.074)
| |
-2.895
|
(-3.712, -2.078)
| |
|
ΔHematocrit (mmol/mol)
|
|
CCB
|
-0.003
|
(-0.005, -0.001)
|
0.0103 *
|
-0.003
|
(-0.005, -0.001)
|
0.0092 *
|
|
ARB
|
-0.007
|
(-0.01, -0.005)
| |
-0.007
|
(-0.01, -0.005)
| |
- Δ indicates mean change in laboratory test value between baseline and exposure period. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltransferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (ARB vs CCB). † Analyses were adjusted by covariates including age, sex, medical history and previous drugs.
