Effect of sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) and BAY 41-2272 on washed platelet aggregation (panel A) and cyclic GMP production (panel B) in rats fed with a standard chow diet (SCD) or high-fat diet (HFD) during 10 weeks. Washed platelets (1.2 × 108 platelets/ml) from SCD or HFD rats were stimulated with ADP (10 μM) in the absence or the presence of SNP, SNAP or BAY 41-2272 (10 μM each). Results are shown as mean ± SEM values (n = 4-7). *P < 0.05 compared with untreated control group. #P < 0.05 compared with the respective agent in control group.