Effect of N-Acetylcysteine (NAC) and PEG-catalase on washed platelet aggregation of rats fed with a standard chow diet (SCD) or high-fat diet (HFD) during 10 weeks. Washed platelets (1.2 × 108 platelets/ml) from SCD or HFD rats were stimulated with thrombin (100 mU/ml; panel A) or ADP (10 μM; panel B) in the absence or the presence of NAC (1 mM) or PEG-catalase (1000 U/ml). Results are shown as mean ± SEM values (n = 4-7). *P < 0.05 compared with untreated control group. #P < 0.05 compared with the respective untreated platelets.