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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways

Figure 5

GBE inhibits high-glucose-induced activation of STAT1 and STAT3 as well as ICAM-1 accumulation in HAECs. (A) HAECs were incubated in high glucose for 3 days, followed by incubation with GBE, fludarabine (STAT1 inhibitor;20 μmol/l), or piceatannol (10 μmol/l) for 1 day. (B) HAECs were incubated in high glucose for 3 days, followed by incubation with GBE, fludarabine, piceatannol, fludarabine plus GBE, or piceatannol plus GBE for 1 day. (C and D) EMSAs for STAT1 and STAT3 were performed using nuclear extracts from human aortic endothelial cells that were cultured in high glucose or mannitol for 3 days, followed by treatment with GBE. Quantification of STAT1 and STAT3 activation in HAECs treated with high glucose combined with GBE is also shown. N = 6 in each set of experiment. *p < 0.05 compared to control group; # p < 0.05 compared to the high-glucose or mannitol groups.

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Cardiovascular Diabetology

ISSN: 1475-2840