Figure 4

Effects of AGEs on the productions of the vasodilators, NO and PGI ₂ , in late EPCs. Late EPCs were incubated in medium containing AGEs of concentrations between 0 ~ 500 μg/ml for 24 h, and the cultured media were then collected. A: The amount of NO was determined by ELISA. B: The production of 6-keto-prostaglandin F_1α (6-keto-PGF_1α), the PGI₂ stable degenerative product, was determined by ELISA. Data represent the mean ± SE of four different experiments. *p < 0.05, **p < 0.01 vs. control.