Skip to main content

Table 2 Relationship between CTGF − 945 G/C genotypes and cardiac structure, cardiac function and kidney function parameters.

From: The CTGF gene −945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes

 

−945 G/C genotypes

  

P values

   
 

GG

GC

CC

Additive model (unadjusted)

Additive model (adjusted)†

Dominant model (adjusted)†

Recessive model (adjusted)†

n

161

227

107

    

Cardiac structure

       

LV mass index (g/m2)

100.2 ± 26.3

98.3 ± 28.2

97.6 ± 23.2

0.73

0.43

0.26

0.90

Cardiac function

       

Diastolic function, E/A ratio

1.00 ± 0.30

1.00 ± 0.38

1.01 ± 0.38

0.94

0.89

0.84

0.64

E/e´ ratio*

10.00 [7.10 - 13.92]

9.89 [7.53 - 19.00]

9.74 [6.8 - 12.98]

0.51

0.55

0.95

0.35

Systolic function, LVEF (%)

67 ± 11

68 ± 12

69 ± 10

0.19

0.32

0.16

0.33

Kidney function

       

eGFR (ml/min/1.73 m2)

76.5 ± 25.9

72.7 ± 25.8

75.4 ± 25.3

0.44

0.19

0.09

0.98

24-hr urinary albumin excretion (μg/min) *

12.4 [8.2 - 44.0]

14.4 [7.8 - 47.8]

12.8 [8.6 - 35.2]

0.74

0.46

0.28

0.92

  1. Data is expressed as mean ± SD, *Median [25th, 75th quartiles]. LVEF, left ventricle ejection fraction; eGFR, estimated glomerular filtration rate. †Genetic models are adjusted for age, gender, BMI, systolic and diastolic blood pressure and hypertension.