Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts

Table 4 Blood Glucose Concentrations (mg/dl)

	Number	Baseline	Preocclusion	Occlusion 30 min	Reperfusion
					1 hr	2 hr
CON	14	92 ± 23	89 ± 19	109 ± 40	129 ± 43	111 ± 34
MIL10	8	114 ± 75	105 ± 52	132 ± 60	124 ± 56	105 ± 70
MIL30	9	93 ± 23	82 ± 20	107 ± 51	98 ± 46	79 ± 29
LEV3	7	116 ± 40	89 ± 24	138 ± 66	120 ± 80	106 ± 49
LEV10	9	99 ± 39	97 ± 28	122 ± 51	113 ± 33	101 ± 41
HG CON	10	90 ± 16	355 ± 121*^†	286 ± 137*^†	361 ± 140*^†	273 ± 144*^†
HG MIL30	7	87 ± 16	343 ± 95*^†	351 ± 62*^†	295 ± 150*^†	246 ± 140*^†
HG LEV10	9	88 ± 17	320 ± 97*^†	311 ± 120*^†	321 ± 142*^†	285 ± 161*^†
HG LEV30	7	98 ± 32	341 ± 83*^†	390 ± 99*^†	313 ± 124*^†	293 ± 153*^†
HG LEV100	7	110 ± 45	447 ± 84*^†	394 ± 113*^†	408 ± 140*^†	385 ± 161*^†
ATR	6	82 ± 38	87 ± 25	93 ± 14	87 ± 25	85 ± 12
MIL30 + ATR	8	80 ± 27	80 ± 15	101 ± 49	90 ± 58	77 ± 47
LEV10 + ATR	7	100 ± 32	100 ± 36	124 ± 57	147 ± 94	123 ± 80
HG MIL30 + ATR	7	74 ± 29*	317 ± 70*^†	376 ± 31*^†	293 ± 191*^†	241 ± 197*^†
HG LEV100 + ATR	9	76 ± 13	341 ± 145*^†	379 ± 106*^†	381 ± 149*^†	311 ± 131*^†

Data are mean ± SD.
CON = control; MIL10 or 30 = 10 or 30 μg/kg milrinone; LEV 3, 10, 30 or 100 = 3, 10, 30 or 100 μg/kg levosimendan; HG = hyperglycemia; ATR = atractyloside.
*Significantly (P < 0.05) different from baseline. †Significantly (P < 0.05) different from CON.

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