Figure 4

Early and Late EPCs. Schematic illustrating the two major types of cell colonies arising from blood and bone marrow mononuclear cells. Short term colonies appear within 7days of culture and are comprised of spindle shape or polymorphic cells. These early EPCs (also called angiogenic EPCs) express a number of endothelial and hematopoietic markers but fail to proliferate in culture. Late colonies, appearing from 721days, are comprised of epitheloid cells with high proliferative capacity. These late EPCs (also called vasculogenic EPCs) express all markers of mature endothelial cells but lack hematopoietic marker expression.