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Table 7 Fasting lipid concentration according to apoE4-bearing genotypes

From: Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

 

Control

T2DM

T2DM + CAD

Total

Variables (mg/dL)

E3/E3

E4-bearing genotypes

E3/E3

E4-bearing genotypes

E3/E3

E4-bearing genotypes

E3/E3

E4-bearing genotypes

 

(n = 113)

(n = 22)

(n = 117)

(n = 35)

(n = 88)

(n = 47)

(n = 318)

(n = 104)

TC

191.58 (2.02)

194.09 (5.22)

232.80 (5.33)

234.77 (8.65)

206.52 (5.26)

192.04 (7.96)

210.88 (2.72)

206.86 (5.11)

LDL-C

110.87 (1.97)

118.52 (4.45)

145.14 (4.54)

140.91 (8.43)

125.33 (4.84)

113.80 (7.33)

127.48 (2.39)

123.92 (4.59)

HDL-C

60.07 (1.43)

55.77 (2.51)

50.84 (1.13)

48.63 (2.98)

45.49 (1.27)

42.70 (1.37)

52.64 (0.81)

47.46 (1.37)**

VLDL-C

20.04 (0.87)

20.18 (1.69)

41.38 (1.99)

55.77 (5.85)*

41.25 (2.37)

38.91 (3.04)

33.76 (1.17)

40.62 (2.72)**

TG

100.20 (4.33)

100.91 (8.48)

206.92 (9.99)

278.83 (29.63)*

206.26 (11.78)

194.53 (15.21)

168.82 (5.88)

203.10 (13.62)**

Non-HDL-C

131.50(2.16)

138.32(4.99)

181.97(5.36)

186.14(8.12)

161.03(5.24)

149.34(7.44)

158.24 (2.83)

159.39 (4.82)

  1. E4-bearing genotypes = E3/E4, E4/E4, E2/E4. Independent sample t-test test was applied to compare between E3/E3 and E4-bearing genotypes. Data are presented as mean values (SEM).
  2. *p-value < 0.05 in comparison between E3/E3 and E4-bearing genotypes in T2DM.
  3. **p-value < 0.01 in comparison between E3/E3 and E4-bearing genotypes in total subjects.