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Table 5 Association of apoE gene polymorphism with the risk of T2DM and CAD compared to healthy controls represented as adjusted OR

From: Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

 

T2DM

T2DM + CAD

 

Adjusted OR (95% CI)††

p-value

Adjusted OR (95% CI)††

p-value

E3/E4 genotype

1.42 (0.72 - 2.78)

0.310

2.52 (1.28 - 4.97)

0.008††

ε4 allele

2.04 (1.07 - 3.86)

0.029††

2.32 (1.17 - 4.61)

0.016††

Age

1.00 (0.97 - 1.04)

0.887

1.13 (1.08 - 1.18)

<0.0001

Sex

1.29 (0.77 - 2.14)

0.326

3.10 (1.75 - 5.49)

<0.0001

BMI

3.68 (2.25 - 6.00)

<0.0001

3.66 (2.09 - 6.39)

<0.0001

Smoking

2.58 (0.87 - 7.66)

0.086

0.59 (0.13 - 2.50)

0.473

Physical activity

0.68 (0.40 - 1.19)

0.148

0.67 (0.36 - 1.24)

0.206

  1. ††After adjusting for age, sex, BMI, smoking habit and physical activity. Normal reference ranges of clinical and biochemical data are described in materials and methods.
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Cardiovascular Diabetology

ISSN: 1475-2840