Table 4 Associations of apoE gene polymorphisms with the risk of T2DM and CAD compared to healthy controls represented as unadjusted OR
Genotype | Controls (n = 149) | T2DM (n = 155) | Unadjusted OR (95% CI) | p-value | T2DM + CAD (n = 147) | Unadjusted OR (95% CI) | p-value |
|---|---|---|---|---|---|---|---|
E2/E2 | 2 | 1 | 0.48 (0.02 - 6.78) | 0.616 | 1 | 0.50 (0.02 - 7.16) | 1.000 |
E3/E3 | 113 | 117 | 0.98 (0.56 - 1.71) | 0.942 | 88 | 0.48 (0.28 - 0.81) | 0.003 |
E4/E4 | 1 | 4 | 3.92 (0.41 - 93.19) | 0.371 | 1 | 1.01(0.06 - 16.36) | 1.000 |
E2/E3 | 12 | 2 | 0.15 (0.02 - 0.72) | 0.005 | 11 | 0.92(0.36 - 2.33) | 0.854 |
E2/E4 | 0 | 1 | - | 1.000 | 0 | - | - |
E3/E4 | 21 | 30 | 1.46 (0.76 - 2.81) | 0.219 | 46 | 2.78(1.50 - 5.16) | 0.0004 |
Allele ε2 | 16 | 5 | 0.29 (0.09 - 0.85) | 0.011 | 13 | 0.81(0.36 - 1.81) | 0.580 |
Allele ε3 | 259 | 266 | 0.91 (0.56 - 1.48) | 0.691 | 234 | 0.57(0.36 - 0.90) | 0.107 |
Allele ε4 | 23 | 39 | 1.72 (0.97 - 3.06) | 0.047 | 49 | 2.37(1.36 - 4.15) | 0.0009 |