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Table 2 Hemodynamic parameters and calcium measurements during control perfusion in non-diabetic and diabetic hearts

From: The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice

 

db/+

db/db

db/+

cariporide

db/db

cariporide

 

(n = 9)

(n = 9)

(n = 8)

(n = 8)

LVDP (mmHg)

103.9 ± 4.9

103.5 ± 8.5

104.2 ± 5.6

102.4 ± 7.8

Heart rate (bpm)

370.3 ± 16.2

309.6 ± 25.0*

358.6 ± 16.8

307.9 ± 18.9

dP/dt max (mmHg/ms)

3.70 ± 0.20

2.98 ± 0.33

3.71 ± 0.30

2.96 ± 0.20

dP/dt min (mmHg/ms)

3.04 ± 0.14

2.35 ± 0.21*

3.06 ± 0.25

2.34 ± 0.18

Diast ratio (a.u.)

1.31 ± 0.04

1.37 ± 0.02

1.32 ± 0.08

1.38 ± 0.05

Ca-T amp (a.u.)

0.60 ± 0.04

0.51 ± 0.03

0.59 ± 0.06

0.50 ± 0.07

TTP (ms)

37.5 ± 1.4

45.8 ± 5.1*

38.8 ± 1.3

45.6 ± 3.3

DT50 (ms)

62.1 ± 2.0

81.1 ± 4.7*

63.0 ± 1.4

82.3 ± 4.2

DT100 (ms)

128.1 ± 4.3

150.1 ± 14.6

130.4 ± 4.1

149.8 ± 11.5

  1. Values are the means ± SE. LVDP, left ventricular developed pressure; dP/dt max and dP/dt min, maximum and minimum first derivatives of developed pressure; Diast ratio, diastolic fura-2 fluorescence ratio; Ca-T amp, amplitude of Ca2+ transient; a.u., arbitrary unit; TTP, time-to-peak Ca2+ transient; DT50, 50% decay-time of Ca2+ transient, DT100, 100% decay-time of Ca2+ transient. Background autofluorescence was subtracted for fura-2 fluorescence study. * p < 0.05 vs db/+ mice
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Cardiovascular Diabetology

ISSN: 1475-2840