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Table 3 Pharmacokinetic properties of ARBs [49, 50, 79]

From: What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?

 

tmax(h)

Bioavailability (%)

T1/2

(h)

Vd

(L)

Interaction with food

Hepatic elimination (%)

Candesartan

3.0-5.0

42

9-13

0.13 (L/kg)

No

67

Eprosartan

2.0-6.0

13

5-7

308

No

90

Irbesartan

1.0-2.0

60-80

12-20

53-93

No

80

Losartan

1.0 (3.0-4.0)1

33

2 (4-6)1

34 (12)1

No

60

Olmesartan

1.4-2.8

262

11.8-14.7

15-20

No

51-663

Telmisartan

1

43

24

500

No

> 984

Valsartan

2

23

7

17

No

83

Azilsartan

1.5-3.0

60

11

16

No

55

  1. Abbreviations: ARB = angiotensin II receptor blocker; t1/2 = terminal elimination half-life; tmax = time to maximum plasma concentration; Vd = volume of distribution
  2. 1 Values in parentheses are for the active metabolite of losartan
  3. 2 For olmesartan medoxomil
  4. 3 Based on urinary recovery rate for intravenous olmesartan
  5. 4 Faecal recovery for telmisartan
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Cardiovascular Diabetology

ISSN: 1475-2840