High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels

Table 4 Blood glucose concentration (mg/dl)

	Baseline	Before ischemia	Just after reperfusion	1 h after reperfusion	2 h after reperfusion
CON	88 ± 15	91 ± 19	112 ± 27	105 ± 32	101 ± 20
LF	95 ± 11	109 ± 14	122 ± 26	118 ± 26	100 ± 23
HF	89 ± 17	87 ± 13	111 ± 33	93 ± 35	95 ± 26
DIA	90 ± 14	88 ± 14	107 + 31	120 ± 35	107 ± 28
5HD	89 ± 12	85 ± 16	101 ± 28	108 ± 18	111 ± 28
HF + 5HD	87 ± 8	86 ± 9	105 ± 24	101 ± 26	104 ± 24
HG	92 ± 12	349 ± 32*^†	360 ± 50*^†	353 ± 28*^†	100 ± 39
LF + HG	92 ± 13	338 ± 24*^†	378 ± 57*^†	327 ± 29*^†	105 ± 42
HF + HG	92 ± 12	341 ± 25*^†	374 ± 52*^†	337 ± 47*^†	110 ± 28
DIA + HG	91 ± 13	349 ± 22*^†	350 ± 53*^†	353 ± 28*^†	106 ± 37

Data are mean ± SD, and n = 10 for each.
CON = control; LF or HF = 0.15 or 0.5 mg/kg fasudil hydrochloride; DIA = 10 mg/kg diazoxide; 5HD = 5-hydroxydecanoic acid; HG = hyperglycemia.
*Significantly (p < 0.05) different from baseline.
†Significantly (p < 0.05) different from control.

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