Groups | Treatments |
---|---|
CON | Saline, i.v. bolus just before reperfusion. |
LF | Low-dose fasudil (0.15 mg/kg), i.v. bolus just before reperfusion. |
HF | High-dose fasudil (0.5 mg/kg), i.v. bolus just before reperfusion. |
DIA | Diazoxide (10 mg/kg), i.v. bolus just before reperfusion. |
HG | Saline, i.v. bolus just before reperfusion, and continuous infusion of 50% glucose in water starting at 15 min before LAD occlusion and lasting until 60 min after reperfusion. The target blood glucose concentration was 350 mg/dl. |
LF + HG | Same as group HG except for low-dose fasudil (0.15 mg/kg) in place of saline. |
HF + HG | Same as group HG except for low-dose fasudil (0.5 mg/kg) in place of saline. |
DIA + HG | Same as group HG except for diazoxide (10 mg/kg) in place of saline. |
5HD | 5HD (10 mg/kg), i.v. at 5 min before reperfusion followed by saline, i.v. bolus just before reperfusion. |
HF + 5HD | Same as group 5HD except for high-dose fasudil (0.5 mg/kg) in place of saline. |