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Table 5 Comparison of clinical features between subjects without and with subcutaneous fat accumulation (SFA cutoff value 128 cm2; median value) and hyperinsulinemia (IRI cutoff value 5.5 μIU/mL; median value) (Analysis 3) (n = 500)

From: Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution

  SFA < 128 cm2   SFA ≥128 cm2  
  IRI < 5.5 μIU/mL IRI ≥5.5 μIU/mL IRI < 5.5 μIU/mL IRI ≥5.5 μIU/mL
Age, years 55 ± 9 55 ± 10 55 ± 9 52 ± 9
BMI, kg/m2 21.9 ± 1.9 23.4 ± 1.9* 24.7 ± 1.9* 26.6 ± 2.8†§
VFA, cm2 88 ± 43 128 ± 48* 131 ± 41* 164 ± 43†§
SFA, cm2 91 ± 27 104 ± 21* 157 ± 31* 187 ± 50†§
Blood glucose, mg/dL 106 ± 20 115 ± 19* 108 ± 16 111 ± 16
Fasting IRI, μIU/mL 3.7 ± 1.1 7.4 ± 1.9* 4.4 ± 0.9* 10.4 ± 5.4†§
HbA1c (NGSP),% 5.7 ± 0.5 5.9 ± 0.7* 5.8 ± 0.6 5.8 ± 0.5
SBP, mmHg 120 ± 13 126 ± 13* 123 ± 11* 124 ± 10
DBP, mmHg 76 ± 8 79 ± 7* 78 ± 11 80 ± 7
Triglyceride, mg/dL 117 ± 81 157 ± 114* 145 ± 117* 153 ± 83
HDL-cholesterol, mg/dL 62 ± 13 55 ± 11* 56 ± 12* 51 ± 12†§
LDL-cholesterol, mg/dL 119 ± 31 124 ± 30 118 ± 24 128 ± 26§
eGFR, mL/min 75 ± 13 74 ± 15 73 ± 11 73 ± 12
  1. Data are mean ± SD
  2. *p < 0.01, compared to with SFA < 128 cm2 and IRI < 5.5 μIU/mL
  3. p < 0.01, compared to with SFA < 128 cm2 and IRI ≥5.5 μIU/mL
  4. §p < 0.01 compared to with SFA ≥128 cm2 and IRI < 5.5 μIU/mL