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Table 3 Comparison of clinical features between subjects without and with obesity (BMI cutoff value 25 kg/m2) and hyperinsulinemia (IRI cutoff value 5.5 μIU/mL; median value) (Analysis 1) (n = 500)

From: Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution

  BMI < 25 kg/m2   BMI ≥ 25 kg/m2  
  IRI < 5.5 μIU/mL IRI ≥ 5.5 μIU/mL IRI < 5.5 μIU/mL IRI ≥ 5.5 μIU/mL
Age, years 55 ± 9 54 ± 10 55 ± 8 53 ± 9
BMI, kg/m2 22.1 ± 1.8 23.2 ± 1.2* 26.2 ± 1.5* 27.6 ± 2.4†§
VFA, cm2 94 ± 44 131 ± 40* 144 ± 36* 171 ± 45†§
SFA, cm2 103 ± 36 127 ± 33* 154 ± 42* 191 ± 58†§
Blood glucose, mg/dL 106 ± 15 114 ± 20* 114 ± 33* 111 ± 13
Fasting IRI, μIU/mL 3.8 ± 1.1 7.8 ± 2.6* 4.5 ± 0.8* 11.0 ± 5.8†§
HbA1c (NGSP),% 5.7 ± 0.5 5.8 ± 0.7* 6.0 ± 0.9* 5.8 ± 0.5
SBP, mmHg 120 ± 12 124 ± 11* 126 ± 11* 125 ± 10
DBP, mmHg 76 ± 8 79 ± 7* 78 ± 14 80 ± 7
Triglyceride, mg/dL 117 ± 88 148 ± 99* 171 ± 112* 161 ± 89
HDL-cholesterol, mg/dL 61 ± 13 55 ± 12* 54 ± 8* 51 ± 11
LDL-cholesterol, mg/dL 117 ± 28 121 ± 27 124 ± 30 131 ± 27
eGFR, mL/min 74 ± 13 76 ± 13 74 ± 11 71 ± 13
  1. Data are mean ± SD
  2. *p < 0.01, compared to with BMI < 25 kg/m2 and IRI < 5.5 μIU/mL
  3. p < 0.01, compared to with BMI < 25 kg/m2 and IRI ≥ 5.5 μIU/mL
  4. §p < 0.01 compared to with BMI ≥ 25 kg/m2 and IRI < 5.5 μIU/mL