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Table 3 Comparison of proinflammatory cytokines and oxidative markers before and after 75 g oral glucose tolerance test (75 g-OGTT) in patients categorized according to glucose tolerance status and the presence of CAD

From: Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes

 

NGT (n = 50)

IGT (n = 41)

T2DM (n = 29)

 

CAD (n = 18)

Non-CAD (n = 32)

CAD (n = 28)

Non-CAD (n = 13)

CAD (n = 19)

Non-CAD (n = 10)

PG (mg/dl)

      

PG-0

99 ± 11

98 ± 12

102 ± 11

100 ± 13

112 ± 13

108 ± 17

PG-30

163 ± 36

173 ± 43

175 ± 31

182 ± 13

203 ± 47

188 ± 34

PG-60

165 ± 44

165 ± 42

196 ± 38

204 ± 42

248 ± 60

216 ± 40

PG-90

152 ± 27

138 ± 28

187 ± 31

186 ± 21

257 ± 52

225 ± 43

PG-120

118 ± 15

112 ± 23

172 ± 17

170 ± 14

250 ± 51

246 ± 29

PG-150

114 ± 29

88 ± 23

148 ± 33

139 ± 19

204 ± 65

164 ± 57

PG-180

83 ± 26

85 ± 19

127 ± 40

104 ± 31

172 ± 69

167 ± 56

TNF-α (pg/ml)

      

TNF-α (0)

3.8 (3.4-4.9)

3.8 (3.5-4.0)

3.9 (3.6-4.9)

3.6 (3.0-4.2)

3.8 (3.6-4.0)

3.9 (3.4-4.3)

TNF-α (60)

5.7 (5.1-5.9)

5.3 (5.0-5.8)

5.7 (5.4-6.1)

5.3 (5.2-5.9)

5.8 (5.5-5.9)

5.4 (5.3-6.7)

TNF-α (120)

6.4 (5.9-7.9)

6.5 (5.5-6.8)

7.5* (6.8-8.3)

6.4 (3.5-7.1)

7.6† (6.5-7.8)

6.2 (5.8-8.1)

IL-6 (pg/ml)

      

IL-6 (0)

2.5 (2.2-3.4)

2.5(2.3-3.1)

3.2 (2.4-3.4)

3.0 (2.3-3.5)

2.5(2.0-3.4)

3.2(2.6-3.4)

IL-6 (60)

4.2(3.7-4.9)

4.0(3.9-4.2)

4.4 (3.7-5.0)

4.3 (3.7-4.6)

4.5(3.7-5.2)

4.3(3.8-4.6)

IL-6 (120)

4.7(4.4-5.0)

4.4(3.9-4.9)

5.0 (4.4-7.2)

4.4 (3.5-5.4)

5.2(3.0-5.8)

4.8(4.3-5.0)

NT (μ mol/l)

      

NT (0)

0.23 (0.12-0.24)

0.17 (0.15-0.23)

0.17 (0.14-0.23)

0.18 (0.04-0.25)

0.20 (0.18-0.23)

0.17 (0.14-0.18)

NT (60)

0.34 (0.21-0.36)

0.33 (0.25-0.35)

0.33 (0.28-0.38)

0.35 (0.16-0.36)

0.35 (0.31-0.39)

0.29 (0.26-0.37)

NT (120)

0.92 (0.65-1.02)

0.84 (0.72-0.87)

0.98* (0.80-1.19)

0.88 (0.76-0.98)

1.02† (0.85-1.27)

0.87 (0.79-1.16)

  1. Data are displayed in mean ± SD or median (interquartile range); *p < 0.05 represents the significant differences between normal and CAD in IGT group; †P < 0.05 represents the significant differences between normal and CAD in T2DM group; IL-6: interleukin-6; NT: nitrotyrosine; PG: plasma glucose; TNF-α: tumor necrosis factor-alpha