TY - JOUR AU - Chu, Chih-Sheng AU - Lee, Kun-Tai AU - Cheng, Kai-Hong AU - Lee, Min-Yi AU - Kuo, Hsuan-Fu AU - Lin, Tsung-Hsien AU - Su, Ho-Ming AU - Voon, Wen-Chol AU - Sheu, Sheng-Hsiung AU - Lai, Wen-Ter PY - 2012 DA - 2012/03/07 TI - Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes JO - Cardiovascular Diabetology SP - 21 VL - 11 IS - 1 AB - Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by oxidative stress. We hypothesized that postchallenge proinflammatory and nitrosative responses after 75 g oral glucose tolerance tests (75 g-OGTT) might be associated with CAD in patients without previously recognized type 2 diabetes mellitus (T2DM). SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-11-21 DO - 10.1186/1475-2840-11-21 ID - Chu2012 ER -