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Table 4 Adjusted-odds ratio (95% CI) of subgroups for carotid atherosclerosis according to quartile of uric acid by gender

From: Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome

   Men Women
Uric acid range (mg/dl)
Characteristics
N UA-1
0.8-4.3
UA-2
4.4-5.5
UA-3
5.6-6.8
UA-4
6.9-16.1
P for trend* N UA-1
0.5-3.8
UA-2
3.9-4.7
UA-3
4.8-6.0
UA-4
6.1-15.4
P for
trend*
Age             
   < 75 years 241 1 (reference) 0.72 (0.33-1.60) 0.99 (0.46-2.14) 1.08 (0.44-2.64) 0.802 293 1 (reference) 1.63 (0.80-3.34) 1.35 (0.65-2.79) 4.11 (1.61-10.5) § 0.020
   ≥75 years 422 1 (reference) 1.33 (0.66-2.67) 2.76 (1.21-6.29) † 3.00 (1.34-6.70) ‡ 0.015 623 1 (reference) 1.49 (0.85-2.63) 1.24 (0.71-2.17) 1.57 (0.87-2.83) 0.400
Body mass index             
   <25 kg/m2 557 1 (reference) 1.08 (0.62-1.88) 1.79 (0.98-3.26) 1.61 (0.86-2.99) 0.162 729 1 (reference) 1.46 (0.90-2.35) 1.38 (0.85-2.26) 1.51 (0.88-2.59) 0.314
   ≥25 kg/m2 106 1 (reference) 1.54 (0.23-10.3) 3.17 (0.49-20.4) 15.1 (1.60-143) † 0.030 187 1 (reference) 1.92 (0.64-5.78) 1.77 (0.63-4.99) 8.66 (2.44-30.8) # 0.001
History of CVD             
   No 348 1 (reference) 1.34 (0.72-2.50) 2.47 (1.26-4.86) ‡ 2.02 (1.01-4.06) † 0.037 557 1 (reference) 2.00 (1.18-3.37) † 1.13 (0.68-1.90) 1.95 (1.10-3.45) † 0.016
   Yes 315 1 (reference) 0.66 (0.25-1.75) 0.93 (0.33-2.62) 1.98 (0.63-6.28) 0.185 359 1 (reference) 0.87 (0.40-1.85) 1.79 (0.77-4.15) 2.93 (1.08-7.92) † 0.037
Medication             
   No 279 1 (reference) 1.23 (0.59-2.54) 2.52 (1.09-5.82) † 3.71 (1.47-9.35) ‡ 0.011 333 1 (reference) 1.69 (0.84-3.41) 1.97 (0.93-4.15) 0.95 (0.41-2.18) 0.178
   Yes 384 1 (reference) 0.89 (0.41-1.90 1.27 (0.60-2.70) 1.19 (0.54-2.64) 0.786 583 1 (reference) 1.36 (0.77-2.40) 1.15 (0.66-1.99) 2.84 (1.52-5.33)§ 0.004
  1. CVD, cardiovascular disease. Medications include antihypertensive, antilipidemic, and antidiabetic medications. Adjusted for age, body mass index, smoking status, systolic blood pressure, diastolic blood pressure, antihypertensive medication, LDL-cholesterol, HDL-cholesterol, triglycerides, antilipidemic medication, fasting plasma glucose, antidiabetic medication, and history of cardiovascular disease. † P < 0.05; ‡ P < 0.01; § P < 0.005; # P < 0.001 vs. the first quartile (UA-1).