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Table 1 Characteristics of subjects

From: Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome

  Men Quartile of serum uric acid   Women Quartile of serum uric acid   
Characteristics Uric acid range (mg/dL) UA-1
0.8-4.3
N = 169
UA-2
4.4-5.5
N = 171
UA-3
5.6-6.8
N = 163
UA-4
6.9-16.1
N = 160
P for
trend*
UA-1
0.5-3.8
N = 247
UA-2
3.9-4.7
N = 213
UA-3
4.8-6.0
N = 235
UA-4
6.1-15.4
N = 221
P for
trend*
Age (years) 76 ± 8 78 ± 7 78 ± 8 79 ± 7 0.004 79 ± 8 78 ± 8 79 ± 8 82 ± 8 < 0.001
Body mass index†(kg/m2) 21.3 ± 4.6 21.9 ± 3.2 21.9 ± 3.9 21.8 ± 4.0 0.372 21.2 ± 3.6 22.1 ± 3.4 22.8 ± 4.8 22.3 ± 4.8 < 0.001
Smoking status‡(never/light/heavy, %) 26.0/20.7/53.3 32.2/19.9/48.0 36.2/17.8/46.0 35.6/16.9/47.5 0.517 99.2/0.4/0.4 96.2/0.5/3.3 65.7/1.3/3.0 93.7/2.7/3.6 0.043
Alcohol consumption¶, N (%) 78 (67.8) 70 (60.9) 65 (59.1) 65 (66.3) 0.470 1 (0.6) 3 (1.8) 6 (3.3) 5 (2.8) 0.286
Systolic blood pressure (mmHg) 132 ± 22 141 ± 22 139 ± 24 136 ± 25 0.003 138 ± 21 139 ± 20 138 ± 21 136 ± 28 0.552
Diastolic blood pressure (mmHg) 76 ± 14 78 ± 13 77 ± 13 76 ± 14 0.672 76 ± 13 76 ± 11 76 ± 13 72 ± 16 0.001
Antihypertensive medication, N (%) 65 (38.5) 75 (43.9) 88 (54.0) 82 (51.3) 0.019 116 (47.0) 105 (49.3) 140 (59.6) 146 (66.1) < 0.001
Total cholesterol (mg/dl) 167 ± 46 168 ± 42 164 ± 41 171 ± 45 0.505 190 ± 40 188 ± 42 193 ± 43 181 ± 44 0.025
LDL-cholesterol (mg/dl) 102 ± 38 104 ± 33 95 ± 35 105 ± 38 0.061 118 ± 33 114 ± 35 120 ± 37 110 ± 35 0.016
Triglyceride (mg/dl) 68 (52-93) 73 (56-98) 76 (57-112) 89 (69-127) < 0.001 69 (54-93) 80 (59-109) 92 (69-124) 94 (67-120) < 0.001
HDL-cholesterol (mg/dl) 49 ± 19 47 ± 15 51 ± 18 45 ± 15 0.024 57 ± 17 56 ± 18 53 ± 15 51 ± 17 < 0.001
Antilipidemic drug use, N (%) 9 (5.3) 7 (4.1) 8 (4.9) 8 (5.0) 0.959 17 (6.9) 13 (6.1) 17 (7.2) 26 (11.8) 0.115
Fasting plasma glucose (mg/dl) 119 (98-152) 112 (95-141) 113 (96-150) 115 (96-139) 0.404 112 (97-146) 108 (94-140) 109 (92-130) 118 (97-155) 0.061
Antidiabetic medication, N (%) 50 (29.6) 35 (20.5) 29 (17.8) 37 (23.1) 0.063 47 (19.0) 48 (22.5) 43 (18.3) 59 (26.7) 0.112
Metabolic syndrome, N(%) 32 (18.9) 50 (29.2) 44 (27.0) 54 (33.8) 0.022 62 (25.1) 71 (33.3) 87 (37.0) 97 (43.9) < 0.001
Cardiovascular disease, N (%) 65 (38.5) 85 (49.7) 82 (50.3) 83 (51.9) 0.055 87 (35.2) 84 (39.4) 97 (41.3) 91 (41.2) 0.448
Ischemic stroke,
N (%)
59 (34.9) 74 (43.3) 73 (44.8) 75 (46.9) 0.131 77 (31.2) 73 (34.3) 78 (33.2) 69 (31.2) 0.869
Ischemic heart disease,
N (%)
11 (6.5) 15 (8.8) 17 (10.4) 16 (10.0) 0.592 15 (6.1) 16 (7.5) 21(8.9) 30 (13.6) 0.031
  1. LDL, low-density lipoprotein; HDL, high-density lipoprotein. Plus-minus values are means ± standard deviation. †Body mass index was calculated using weight in kilograms divided by the square of the height in meters. ‡Smoking status: daily consumption (pack)×duration of smoking (year): never, light (< 20 pack year), and heavy (≥20 pack·year). ¶Alcohol consumption was classified into non-drinker and drinker (available data, n = 1,145). Data for triglycerides and fasting plasma glucose were skewed, and are presented as the median (interquartile range) and were log-transformed for analysis. *P-value: ANOVA or χ2-test.