Skip to main content

Table 2 The echocardiographic measures of patients with plasma NT-proBNP below and above our defined cut-off value

From: NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

 

All patients (n = 200)

Patients with NT-proBNP ≤ 45.2 ng/l (n = 96)

Patients with NT-proBNP > 45.2 ng/l (n = 104)

p-values

Left ventricular structure

    

Left ventricular end-diastolic volume [ml]

127.0 ± 28.9

129 ± 28.5

130 ± 31.9

0.85

Left ventricular end-systolic volume [ml]

52.0 ± 15.5

53.5 ± 16.7

53.9 ± 16.7

0.74

Left atrial volume index biplane [ml/m2]

25.6 ± 6.4

24.5 ± 6.1

26.7 ± .6.7

0.021

LV mass, g,

188.8 ± 52.6

203.1 ± 48.0

180.9 ± 53.5

0.11

LV mass/height2,7, [g/m2.7]

41.2 ± 10.9

39.85 ± 10.8

42.43 ± 10.7

0.10

Left ventricular systolic function

    

Left ventricular ejection fraction [%]

59.5 ± 4.8

58.6 ± 5.7

59.9 ± 4.3

0.50

Peak mitral annular systolic velocity (s') [cm/s]

8.49 ± 1.58

8.71 ± 1.60

8.28 ± 1.54

0.057

Left ventricular diastolic function and grade

    

Isovolumetric relaxation time [ms]

86.1 ± 15.8

88.3 ± 17.6

84.8 ± 14.7

0.14

Mitral valve E-wave deceleration time [ms]

201.0 ± 39.5

203.8 ± 38.0

199.6 ± 40.4

0.48

Mitral valve E-wave deceleration slope [m/s2]

3.7 ± 1.1

3.7 ± 1.1

3.8 ± 1.1

0.088

Peak mitral valve E-velocity [m/s]

0.71 ± 0.15

0.71 ± 0.15

0.71 ± 0.15

0.95

Peak mitral valve A-velocity [m/s]

0.93 ± 0.22

0.82 ± 0.17

0.77 ± 0.17

0.033

E/A ratio

0.93 ± 0.20

0.94 ± 20

0.92 ± 0.23

0.60

Peak early mitral annular diastolic velocity (e' lateral) [cm/s]

8.86 ± 2.34

9.23 ± 2.55

8.50 ± 2.06

0.032

Peak atrial mitral annular diastolic velocity (a') [cm/s]

9.82 ± 2.28

10.21 ± 2.18

9.62 ± 2.31

0.088

E/e' lateral ratio

8.51 ± 2.63

9.10 ± 2.89

7.94 ± 2.71

0.025

Diastolic dysfunction grade I no. (%)

7 (3.5)

2 (2)

6 (6)

0.12

Diastolic dysfunction grade II no. (%)

102 (51)

47 (49)

55 (53)

0.31

Diastolic dysfunction grade III no. (%)

0

0

0

-

Right ventricular structure and function

    

Right atrial volume single plane [ml/m2]

23.7 ± 9.0

22.4 ± 8.7

25.2 ± 9.2

0.033

Mid-RV diameter [cm]

3.9 ± 0.5

4.0 ± 0.5

3.9 ± 0.5

0.34

Tricuspid annular plane systolic excursion ^[cm]

2.65 ± 0.45

2.62 ± 0.43

2.67 ± 0.45

0.47

Peak tricuspid regurgitation gradient ~ [mmHg]

18.2 ± 7.2

17.4 ± 6.8

18.5 ± 7.3

0.44

  1. Our plasma NT-proBNP cut-off value has previously been defined but represented the median P-NT-proBNP in the first 50 patients examined in the study [10].
  2. p-values reflect comparison between patients with high and low plasma NT-proBNP
  3. Data are expressed as means ± SD or medians, interquartile range*
  4. Left ventricular (LV)
  5. Right ventricular (RV)
  6. ^no patients had tricuspid annular plane systolic excursion less than 1.5 cm
  7. ~ 65 of all patients had no tricuspid regurgitation, 111 had discrete and 5 patients had mild tricuspid regurgitation. In 19 patients we were not able to evaluate tricuspid regurgitation.