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Table 4 Risk of incident type 2 diabetes mellitus for cases with normal glucose levels * and cases with elevated glucose levels †

From: Signs of dysregulated fibrinolysis precede the development of type 2 diabetes mellitus in a population-based study

 

Cases with normal glucose levels*

 

Cases with elevated glucose levels†

 

Crude OR

Multivariate model‡

 

Crude OR

Multivariate model‡

 

n cases/n referents

OR (95% CI)

OR (95% CI)

n cases/n referents

OR (95% CI)

OR (95% CI)

tPA

59/103

2.43

1.24

94/157

3.05

1.82

(1.50 - 3.91)§

(0.57 - 2.70)

 

(2.02 - 4.61)§

(1.11 - 2.98)§

PAI-1

57/100

2.66

2.06

95/160

2.20

1.40

(1.66 - 4.25)§

(1.10 - 3.86)§

 

(1.57 - 3.07)§

(0.89 - 2.20)

tPA/PAI-1 complex

59/103

3.23

1.67

95/159

4.80

4.01

(1.93 - 5.41)§

(0.87 - 3.22)

 

(2.90-7.92)§

(1.90 - 8.46)§

VWF

58/102

1.66

1.43

95/159

1.86

1.35

  

(1.13 - 2.46)§

(0.79 - 2.59)

 

(1.35 - 2.58)§

(0.87 - 2.09)

  1. * Fasting plasma glucose (FPG) < 6.1 and 2-hour capillary plasma glucose (2hPG) < 8.9 mmol/L.
  2. † FPG 6.1-6.9 and/or 2hPG 8.9-12.1 mmol/L.
  3. Conditional logistic regression analysis performed with complete data sets. ORs with 95% CIs, per 1 SD increment.
  4. ‡ Model including body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides and one of the fibrinolytic variables (tPA: tissue plasminogen activator; PAI-1: plasminogen activator inhibitor-1 or tPA/PAI-1 complex).
  5. § p < 0.05.
  6. Natural logarithm transformation was used for C-reactive protein, triglycerides, tPA, PAI-1 and tPA/PAI-1 complex.
  7. OR: odds ratio; CI: confidence interval; SD: standard deviation.