| | Crude OR | Multivariate model 1* | Multivariate model 2† | Multivariate model 3‡ |
|---|
| | n cases/n referents | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
|---|
tPA | 153/260 | 2.78 | 1.79 | 1.54 | 1.22 |
(2.04 - 3.79)§ | (1.27 - 2.53)§ | (1.06 - 2.23)§ | (0.77 - 1.94) |
PAI-1 | 152/260 | 2.35 | 1.86 | 1.61 | 1.60 |
(1.79 - 3.09)§ | (1.34 - 2.59)§ | (1.14 - 2.28)§ | (1.03 - 2.47)§ |
tPA/PAI-1 complex | 154/262 | 4.05 | 2.92 | 2.45 | 1.70 |
(2.83 - 5.79)§ | (1.92 - 4.43)§ | (1.56 - 3.84)§ | (1.02 - 2.82)§ |
VWF | 153/261 | 1.78 | 1.43 | 1.33 | 1.33 |
| | | (1.39 - 2.29)§ | (1.04 - 1.94)§ | (0.95 - 1.85) | (0.88 - 2.02) |
- Conditional logistic regression analysis performed with complete data sets. ORs with 95% CIs, per 1 SD increment.
- * Model 1: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM and physical activity (sedentary/moderate/active).
- † Model 2: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides.
- ‡ Model 3: Adjusted for body mass index, smoking (non/ex/daily smoking), family history of T2DM, physical activity (sedentary/moderate/active), C-reactive protein, systolic blood pressure and triglycerides, fasting glucose level and 2 hour capillary glucose level.
- § p < 0.05.
- Natural logarithm transformation was used for C-reactive protein, triglycerides, tPA, PAI-1, tPA/PAI-1 complex and VWF.
- OR: odds ratio; CI: confidence interval; SD: standard deviation; T2DM: type 2 diabetes mellitus; tPA: tissue plasminogen activator; PAI-1: plasminogen activator inhibitor-1; VWF: von Willebrand factor.
