Skip to main content

Table 3 Ranking of up- and downregulated pathways in intima-media of type 2 diabetic patients vs. control subjects using GO-Elite 1.19

From: Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes

MAPP Name

Changed

Measured

On MAPP

Changed

Z

Permute

FWER

 

(n)

(n)

(n)

(%)

score

p-value

p-value

Upregulated pathways

       

Triacylglyceride synthesis

3

22

24

13.64

4.7

0.002

0.23

Apoptosis

4

83

85

4.82

2.5

0.04

0.67

Matrix metalloproteinases

2

30

32

6.67

2.4

0.04

0.67

Adipogenesis

5

129

133

3.88

2.3

0.04

0.67

Downregulated pathways

       

Cholesterol biosynthesis

4

15

15

26.67

4.8

0.004

0.15

TNFalpha NFkB netpath 9

16

187

208

8.56

3.8

0.003

0.15

Krebs TCA cycle

5

32

39

15.63

3.7

0.007

0.18

Non-homologous end joining

2

7

8

28.57

3.6

0.04

0.61

Signaling of hepatocyte growth factor receptor

5

35

36

14.29

3.5

0.02

0.39

  1. Shown are significantly up- and downregulated pathways in intima-media of diabetic patients vs. control subjects. Only non-redundant pathways with a z-score above 2.0 are listed. A foldchange of 1.05 and a p-value < 0.05 were used as filtering criteria. Changed (n): number of changed genes, Measured (n): number of genes on the chip, On MAPP (n): number of genes on the MAPP, Changed (%): percentage of changed genes, FWER: family wise error rate
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840