Effects of telmisartan on AMPK/SIRT1 pathway in C2C12 myocytes. On day 5, C2C12 myocytes were treated with telmisartan (indicated concentrations) for 12 h and analyzed by semi-quantitative RT-PCR. GAPDH was used as an internal control. Values shown represent the means ± S.E (n = 3-5). *p < 0.05 vs. 0 μM or baseline, by Fisher’s PLSD.