Figure 3

Effects of telmisartan on the morphology and mass of pancreatic islets in db/db mice fed a high-fat diet. Representative sections of paraffin-embedded serial sections of pancreata (5-μm m thickness) in wild type mice or db/db mice fed a high-fat diet with CMC, telmisartan, or telmisartan + GW9662 were stained for hematoxylin and eosin (HE). The size of pancreatic islets was determined from manually traced islet area. Values shown represent means ± S.E (n = 115-150). †p < 0.05 vs. CMC by Fisher’s PLSD.