Effects of telmisartan on db/db mice fed a high-fat diet. In db/db mice fed a high-fat diet with CMC (○, n = 6), telmisartan (·, n = 6), or telmisartan + GW9662 (△, n = 7) for 5 weeks, body weight (A), food intake (B), systolic blood pressure (C), blood glucose (D), glucose levels during the insulin tolerance test (E), and fasting insulin levels (F) were measured. Values for wild type mice fed normal chow (□, n = 7) are also shown for reference. Glucose levels during the insulin tolerance test were measured after intraperitoneal injection with 0.75 U/kg insulin. Values shown represent means ± S.E. *p < 0.05 vs. 0 min and †p < wild type, by Fisher’s PLSD.